Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 5009772..5010439 Replicon chromosome
Accession NZ_CP077293
Organism Klebsiella aerogenes strain FDAARGOS 1442

Toxin (Protein)


Gene name ypjF Uniprot ID A0A0H3FNF1
Locus tag I6L72_RS23705 Protein ID WP_015703842.1
Coordinates 5010119..5010439 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0H3FLG0
Locus tag I6L72_RS23700 Protein ID WP_015703841.1
Coordinates 5009772..5010098 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L72_RS23675 (I6L72_23675) 5005461..5006354 + 894 WP_015703836.1 50S ribosome-binding GTPase -
I6L72_RS23680 (I6L72_23680) 5006546..5007235 + 690 WP_015703837.1 WYL domain-containing protein -
I6L72_RS23685 (I6L72_23685) 5007297..5008307 + 1011 WP_015703838.1 hypothetical protein -
I6L72_RS23690 (I6L72_23690) 5008400..5009221 + 822 WP_015703839.1 DUF932 domain-containing protein -
I6L72_RS23695 (I6L72_23695) 5009289..5009759 + 471 WP_015703840.1 DNA repair protein RadC -
I6L72_RS23700 (I6L72_23700) 5009772..5010098 + 327 WP_015703841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L72_RS23705 (I6L72_23705) 5010119..5010439 + 321 WP_015703842.1 TA system toxin CbtA family protein Toxin
I6L72_RS23710 (I6L72_23710) 5010686..5011252 + 567 WP_015703843.1 hypothetical protein -
I6L72_RS23715 (I6L72_23715) 5011268..5011462 - 195 WP_015703844.1 toxin-antitoxin system HicB family antitoxin -
I6L72_RS23720 (I6L72_23720) 5011599..5011886 + 288 WP_015703845.1 SymE family type I addiction module toxin -
I6L72_RS23725 (I6L72_23725) 5012110..5013147 + 1038 WP_015703846.1 virulence RhuM family protein -
I6L72_RS23730 (I6L72_23730) 5013432..5014628 - 1197 WP_015703847.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4996245..5013147 16902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12106.95 Da        Isoelectric Point: 5.5873

>T206995 WP_015703842.1 NZ_CP077293:5010119-5010439 [Klebsiella aerogenes]
MNTQPATTPQAAKPCLSPLAVWKMLLTILLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAINFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

>T206995 NZ_CP102836:c4999969-4999052 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12268.98 Da        Isoelectric Point: 6.2003

>AT206995 WP_015703841.1 NZ_CP077293:5009772-5010098 [Klebsiella aerogenes]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRASLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHQHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp

>AT206995 NZ_CP102836:c5000733-4999975 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FNF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FLG0

References