Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4224639..4225296 Replicon chromosome
Accession NZ_CP077293
Organism Klebsiella aerogenes strain FDAARGOS 1442

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag I6L72_RS19890 Protein ID WP_015369792.1
Coordinates 4224639..4225049 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag I6L72_RS19895 Protein ID WP_015369791.1
Coordinates 4225030..4225296 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L72_RS19870 (I6L72_19870) 4220638..4222371 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
I6L72_RS19875 (I6L72_19875) 4222377..4223090 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L72_RS19880 (I6L72_19880) 4223113..4224009 - 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
I6L72_RS19885 (I6L72_19885) 4224110..4224631 + 522 WP_015369793.1 flavodoxin FldB -
I6L72_RS19890 (I6L72_19890) 4224639..4225049 - 411 WP_015369792.1 protein YgfX Toxin
I6L72_RS19895 (I6L72_19895) 4225030..4225296 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
I6L72_RS19900 (I6L72_19900) 4225520..4226503 + 984 WP_015703421.1 tRNA-modifying protein YgfZ -
I6L72_RS19905 (I6L72_19905) 4226602..4227261 - 660 WP_008806429.1 hemolysin III family protein -
I6L72_RS19910 (I6L72_19910) 4227426..4227737 - 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
I6L72_RS19915 (I6L72_19915) 4227788..4228522 + 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
I6L72_RS19920 (I6L72_19920) 4228636..4230069 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T206993 WP_015369792.1 NZ_CP077293:c4225049-4224639 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T206993 NZ_CP102836:c4738779-4738246 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT206993 WP_015369791.1 NZ_CP077293:c4225296-4225030 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206993 NZ_CP102836:c4739056-4738790 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References