Detailed information of TA system TA020699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 20096..20621
• Replicon: plasmid pSLT
• Accession: NC_003277
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: Q93GR5
• Locus tag: PSLT028
• Protein ID: NP_490518.1
• Coordinates: 20316..20621 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: Q93GR6
• Locus tag: PSLT027
• Protein ID: NP_490517.1
• Coordinates: 20096..20314 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PSLT020	15561..15764	+	204	NP_490512.1	hypothetical protein	-
PSLT023	16636..17625	-	990	NP_490513.1	DNA replication	-
PSLT024	17369..17677	+	309	NP_490514.1	hypothetical protein	-
PSLT025	18119..18415	-	297	NP_490515.1	putative cytoplasmic protein	-
PSLT026	18899..19420	-	522	NP_490516.1	putative periplasmic protein	-
PSLT027	20096..20314	+	219	NP_490517.1	toxin addiction system: antidote	Antitoxin
PSLT028	20316..20621	+	306	NP_490518.1	toxin addiction system: toxin	Toxin
PSLT029	20623..20913	+	291	NP_490519.1	putative cytoplasmic protein	-
PSLT030	20910..21431	+	522	NP_490520.1	putative cytoplasmic protein	-
PSLT031	21466..22248	+	783	NP_490521.1	resolvase	-
PSLT032	22257..22808	+	552	NP_490522.1	putative diguanylate cyclase/phosphodiesterase	-
PSLT033	23477..23962	+	486	NP_490523.1	putative inner membrane protein	-
PSLT034	24682..25242	+	561	NP_490524.1	putative adhesin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93933	93933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T20699 NP_490518.1 NC_003277:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T20699 NC_003277:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT20699 NP_490517.1 NC_003277:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT20699 NC_003277:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: Q93GR5

Antitoxin

• AlphaFold DB: Q93GR6