Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2402035..2402774 Replicon chromosome
Accession NZ_CP077293
Organism Klebsiella aerogenes strain FDAARGOS 1442

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag I6L72_RS11150 Protein ID WP_015705365.1
Coordinates 2402035..2402520 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag I6L72_RS11155 Protein ID WP_015705366.1
Coordinates 2402508..2402774 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L72_RS11130 (I6L72_11130) 2397582..2398652 - 1071 WP_015705361.1 mannonate dehydratase -
I6L72_RS11135 (I6L72_11135) 2398913..2399071 + 159 WP_015705362.1 YqaE/Pmp3 family membrane protein -
I6L72_RS11140 (I6L72_11140) 2399128..2400228 - 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
I6L72_RS11145 (I6L72_11145) 2400347..2401963 - 1617 WP_015705364.1 FAD-NAD(P)-binding protein -
I6L72_RS11150 (I6L72_11150) 2402035..2402520 - 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
I6L72_RS11155 (I6L72_11155) 2402508..2402774 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
I6L72_RS11160 (I6L72_11160) 2403047..2404282 + 1236 WP_015705367.1 MFS transporter -
I6L72_RS11165 (I6L72_11165) 2404326..2404823 - 498 WP_015705368.1 heme-binding protein -
I6L72_RS11170 (I6L72_11170) 2404919..2405536 - 618 WP_015705369.1 response regulator -
I6L72_RS11175 (I6L72_11175) 2405536..2406855 - 1320 WP_015705370.1 ATP-binding protein -
I6L72_RS11180 (I6L72_11180) 2406852..2407439 - 588 WP_015705371.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T206984 WP_015705365.1 NZ_CP077293:c2402520-2402035 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T206984 NZ_CP102834:c80768-80463 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT206984 WP_015705366.1 NZ_CP077293:c2402774-2402508 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT206984 NZ_CP102834:c80988-80770 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References