Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 66693..67444 Replicon plasmid unnamed
Accession NZ_CP077292
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag I6L53_RS23445 Protein ID WP_042325831.1
Coordinates 66962..67444 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag I6L53_RS23440 Protein ID WP_042325829.1
Coordinates 66693..66971 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS23435 (I6L53_23435) 64284..66530 - 2247 WP_042325827.1 type IV conjugative transfer system coupling protein TraD -
I6L53_RS23440 (I6L53_23440) 66693..66971 + 279 WP_042325829.1 DUF1778 domain-containing protein Antitoxin
I6L53_RS23445 (I6L53_23445) 66962..67444 + 483 WP_042325831.1 GNAT family N-acetyltransferase Toxin
I6L53_RS23450 (I6L53_23450) 67480..68217 - 738 WP_042325833.1 conjugal transfer complement resistance protein TraT -
I6L53_RS23455 (I6L53_23455) 68404..68964 - 561 WP_042325835.1 hypothetical protein -
I6L53_RS23460 (I6L53_23460) 68976..71873 - 2898 WP_042325838.1 conjugal transfer mating-pair stabilization protein TraG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..88902 88902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-77)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17436.23 Da        Isoelectric Point: 9.3868

>T206982 WP_042325831.1 NZ_CP077292:66962-67444 [Citrobacter farmeri]
MGMRAPEPLTPGHNIAEFCCSDPGLNEWLKKKALKNHSTGISRVYVICAENTNQVIGYYCLSSGSVQRNTAPGPYRRNAP
DSLPVIVLGRLAVDLAYAGKGLGVALLKDAIYRTQNIAVQVGVRALIVHALNDEVKSFYTKFAFEPSSVNPLTLFFPVKL

Download         Length: 483 bp

>T206982 NZ_CP102833:c5030149-5029232 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10507.92 Da        Isoelectric Point: 4.5038

>AT206982 WP_042325829.1 NZ_CP077292:66693-66971 [Citrobacter farmeri]
MKSEAREAPINIRAKTSQRDLIDMAASLVSKSRTDFVLEAACREAQDILLDQRLFILDDQQYDAFLAELDAPITPDRQAR
INDLMGRKSPWE

Download         Length: 279 bp

>AT206982 NZ_CP102833:c5030913-5030155 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References