Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 49457..49982 Replicon plasmid unnamed
Accession NZ_CP077292
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag I6L53_RS23360 Protein ID WP_042325804.1
Coordinates 49677..49982 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag I6L53_RS23355 Protein ID WP_042325802.1
Coordinates 49457..49675 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS23325 (I6L53_23325) 44788..46098 + 1311 WP_042325793.1 fimbrial protein -
I6L53_RS23330 (I6L53_23330) 46174..46755 + 582 WP_042325795.1 hypothetical protein -
I6L53_RS23335 (I6L53_23335) 47321..47563 + 243 WP_156970480.1 hypothetical protein -
I6L53_RS23340 (I6L53_23340) 47880..48053 + 174 WP_042325800.1 YhfL family protein -
I6L53_RS23345 (I6L53_23345) 48130..48561 - 432 Protein_62 transposase -
I6L53_RS23350 (I6L53_23350) 48896..49252 - 357 WP_052425431.1 FKBP-type peptidyl-prolyl cis-trans isomerase N-terminal domain-containing protein -
I6L53_RS23355 (I6L53_23355) 49457..49675 + 219 WP_042325802.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
I6L53_RS23360 (I6L53_23360) 49677..49982 + 306 WP_042325804.1 type II toxin-antitoxin system toxin CcdB Toxin
I6L53_RS23365 (I6L53_23365) 50166..50357 - 192 WP_042325806.1 hypothetical protein -
I6L53_RS23370 (I6L53_23370) 50681..51031 - 351 Protein_67 hypothetical protein -
I6L53_RS23375 (I6L53_23375) 51733..52314 + 582 WP_042325807.1 hypothetical protein -
I6L53_RS23380 (I6L53_23380) 52467..53498 + 1032 WP_042325809.1 Abi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..88902 88902
- flank IS/Tn - - 48046..48495 449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11653.39 Da        Isoelectric Point: 6.4643

>T206981 WP_042325804.1 NZ_CP077292:49677-49982 [Citrobacter farmeri]
MQFRVYTYKRESRYSLFVDVQSNIIDTPGRRMMIPLVSARLLSDKITRELYPVVHIGDDSYRLVTTDMASVPASVIGEEV
SDLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T206981 NZ_CP102833:c4871495-4871211 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGCCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCAGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8348.32 Da        Isoelectric Point: 4.7405

>AT206981 WP_042325802.1 NZ_CP077292:49457-49675 [Citrobacter farmeri]
MKQRITVTIDSDNYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT206981 NZ_CP102833:c4871727-4871485 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References