Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6295931..6296537 Replicon chromosome
Accession NC_003272
Organism Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)

Toxin (Protein)


Gene name hicA Uniprot ID Q8YLM1
Locus tag PCC7120DELTA_RS27930 Protein ID WP_010999401.1
Coordinates 6296241..6296537 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1Z4KPI0
Locus tag PCC7120DELTA_RS27925 Protein ID WP_044522580.1
Coordinates 6295931..6296251 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC7120DELTA_RS27910 6292103..6292972 - 870 WP_010999397.1 hypothetical protein -
PCC7120DELTA_RS27915 6293316..6294059 - 744 WP_010999398.1 Ycf66 family protein -
PCC7120DELTA_RS27920 6294377..6295807 + 1431 WP_010999399.1 NADP-dependent phosphogluconate dehydrogenase -
PCC7120DELTA_RS27925 6295931..6296251 - 321 WP_044522580.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCC7120DELTA_RS27930 6296241..6296537 - 297 WP_010999401.1 type II toxin-antitoxin system HicA family toxin Toxin
PCC7120DELTA_RS27935 6296596..6297726 - 1131 WP_010999402.1 serine/threonine protein kinase -
PCC7120DELTA_RS27940 6297878..6298909 + 1032 WP_010999403.1 hypothetical protein -
PCC7120DELTA_RS27945 6298957..6301269 - 2313 WP_010999404.1 filamentous hemagglutinin N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-75)

Antitoxin

Uncharacterised protein family HicB

(51-101)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10847.17 Da        Isoelectric Point: 5.6514

>T20698 WP_010999401.1 NC_003272:c6296537-6296241 [Nostoc sp. PCC 7120 = FACHB-418]
MGLNSKHQKTLDDIFENPVRSNIPWSDIESMLIALGAEVSEGRGSRVRIALNGVKATFHRPHPEKETDKGAVKSMRRFLT
ESGVQEDLETGGLSDNEI

Download         Length: 297 bp

>T20698 NC_003272:c6296537-6296241 [Nostoc sp. PCC 7120 = FACHB-418]
ATGGGACTTAACAGTAAACATCAAAAAACACTGGATGACATTTTTGAAAATCCCGTTAGATCCAATATTCCTTGGAGTGA
TATTGAGTCTATGCTAATTGCCCTTGGTGCGGAAGTGTCAGAAGGAAGGGGGTCAAGGGTGAGAATAGCTCTTAATGGTG
TCAAGGCGACTTTTCACAGACCACACCCGGAAAAAGAAACCGATAAAGGTGCTGTTAAGTCTATGCGGCGCTTCTTAACA
GAGTCTGGGGTTCAAGAGGACTTGGAGACGGGAGGACTTAGTGACAATGAAATATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12342.13 Da        Isoelectric Point: 4.6723

>AT20698 WP_044522580.1 NC_003272:c6296251-6295931 [Nostoc sp. PCC 7120 = FACHB-418]
MKYKGYEAIVEFDDEAEIFHGEVINLRDVITFQGDSVKELKQAFHDSVDDYLEFCQERGEEPEKPFSGKLMLRINPELHK
IIAIKAKKEGQSLNSWIEKCLCMYVP

Download         Length: 321 bp

>AT20698 NC_003272:c6296251-6295931 [Nostoc sp. PCC 7120 = FACHB-418]
ATGAAATATAAAGGATATGAAGCCATTGTCGAATTTGATGATGAAGCTGAAATTTTTCATGGGGAAGTAATTAACCTTCG
AGATGTGATTACATTTCAGGGTGACAGCGTCAAAGAGCTAAAGCAAGCTTTTCATGATTCAGTAGACGATTATTTAGAAT
TTTGTCAAGAACGTGGCGAAGAACCTGAAAAACCCTTTTCAGGAAAACTCATGCTCAGAATTAACCCTGAATTACATAAA
ATCATCGCCATCAAAGCGAAGAAAGAGGGACAAAGCCTTAATTCTTGGATAGAAAAATGCTTGTGTATGTATGTTCCTTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8YLM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z4KPI0

References