Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4548987..4549618 Replicon chromosome
Accession NZ_CP077291
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name hicA Uniprot ID A0A8H9TXP7
Locus tag I6L53_RS21545 Protein ID WP_042323097.1
Coordinates 4549343..4549618 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8H9TXW0
Locus tag I6L53_RS21540 Protein ID WP_042323095.1
Coordinates 4548987..4549346 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS21515 (I6L53_21515) 4545144..4546088 + 945 WP_042323084.1 nickel ABC transporter permease subunit NikB -
I6L53_RS21520 (I6L53_21520) 4546085..4546918 + 834 WP_042323086.1 nickel ABC transporter permease subunit NikC -
I6L53_RS21525 (I6L53_21525) 4546918..4547682 + 765 WP_042323088.1 nickel import ATP-binding protein NikD -
I6L53_RS21530 (I6L53_21530) 4547679..4548479 + 801 WP_042323091.1 nickel import ATP-binding protein NikE -
I6L53_RS21535 (I6L53_21535) 4548492..4548893 + 402 WP_042323093.1 nickel-responsive transcriptional regulator NikR -
I6L53_RS21540 (I6L53_21540) 4548987..4549346 - 360 WP_042323095.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6L53_RS21545 (I6L53_21545) 4549343..4549618 - 276 WP_042323097.1 type II toxin-antitoxin system HicA family toxin Toxin
I6L53_RS21550 (I6L53_21550) 4549700..4550824 - 1125 WP_042323099.1 ABC transporter permease -
I6L53_RS21555 (I6L53_21555) 4550824..4553562 - 2739 WP_042323101.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10280.05 Da        Isoelectric Point: 10.7792

>T206978 WP_042323097.1 NZ_CP077291:c4549618-4549343 [Citrobacter farmeri]
MRQQVLSLRKKQRSTLEQLFKTPVPQGIKWVDIESLIKALGGEIKEGRGSRCKFLLNKSIACFHRPHPSPDTDKGAVESV
REWLVSIGVKP

Download         Length: 276 bp

>T206978 NZ_CP102833:c2767469-2766147 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGATCACTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13456.34 Da        Isoelectric Point: 4.5718

>AT206978 WP_042323095.1 NZ_CP077291:c4549346-4548987 [Citrobacter farmeri]
MIKLKMPNAMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLDDCREAGIEPYAQQEKLKT
FTLRYPESFGERLSFAAAQEQVSVNTWIIDTLSERLKQA

Download         Length: 360 bp

>AT206978 NZ_CP102833:c2767735-2767469 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTACTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References