Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3615434..3616164 Replicon chromosome
Accession NZ_CP077291
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag I6L53_RS16955 Protein ID WP_042324692.1
Coordinates 3615434..3615802 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag I6L53_RS16960 Protein ID WP_042324694.1
Coordinates 3615823..3616164 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS16945 (I6L53_16945) 3611903..3613477 + 1575 WP_232231109.1 diguanylate cyclase DgcJ -
I6L53_RS23660 3613606..3613829 - 224 Protein_3308 hypothetical protein -
I6L53_RS16950 (I6L53_16950) 3613989..3614705 - 717 WP_042324690.1 YebC/PmpR family DNA-binding transcriptional regulator -
I6L53_RS16955 (I6L53_16955) 3615434..3615802 - 369 WP_042324692.1 TA system toxin CbtA family protein Toxin
I6L53_RS16960 (I6L53_16960) 3615823..3616164 - 342 WP_042324694.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L53_RS16965 (I6L53_16965) 3616175..3616717 - 543 WP_042324696.1 DNA repair protein RadC -
I6L53_RS16970 (I6L53_16970) 3616730..3617173 - 444 WP_042324698.1 antirestriction protein -
I6L53_RS16975 (I6L53_16975) 3617204..3618025 - 822 WP_042324700.1 DUF932 domain-containing protein -
I6L53_RS16980 (I6L53_16980) 3618146..3618619 - 474 WP_042324702.1 hypothetical protein -
I6L53_RS16985 (I6L53_16985) 3618721..3619185 - 465 WP_042324704.1 hypothetical protein -
I6L53_RS16990 (I6L53_16990) 3619495..3620370 - 876 WP_042324706.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3613940..3631672 17732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13622.72 Da        Isoelectric Point: 7.7753

>T206976 WP_042324692.1 NZ_CP077291:c3615802-3615434 [Citrobacter farmeri]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSNETVIKEHIDAGITLVDAVNFLVDKYKLARIDRRGF
TSQEQAPYLTVTDILHARKACGLMNSCSYQDVSNIVLSRSRQ

Download         Length: 369 bp

>T206976 NZ_CP102833:c1808461-1808045 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12725.29 Da        Isoelectric Point: 6.3149

>AT206976 WP_042324694.1 NZ_CP077291:c3616164-3615823 [Citrobacter farmeri]
MKSTDSENDSFLQWGLNRNVTPCFGARLVQGGNRLHYLVDRASITGEFSNAESLKLDEVFPRFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp

>AT206976 NZ_CP102833:c1808688-1808458 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References