Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2371845..2372596 Replicon chromosome
Accession NZ_CP077291
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name ataT Uniprot ID A0A8H9P063
Locus tag I6L53_RS11105 Protein ID WP_042319075.1
Coordinates 2372114..2372596 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A8H9TY90
Locus tag I6L53_RS11100 Protein ID WP_042319074.1
Coordinates 2371845..2372123 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS11085 (I6L53_11085) 2367844..2369205 - 1362 WP_042319070.1 MFS transporter -
I6L53_RS11090 (I6L53_11090) 2369289..2370056 - 768 WP_042319071.1 SDR family oxidoreductase -
I6L53_RS11095 (I6L53_11095) 2370394..2371647 + 1254 WP_042319072.1 enolase C-terminal domain-like protein -
I6L53_RS11100 (I6L53_11100) 2371845..2372123 + 279 WP_042319074.1 DUF1778 domain-containing protein Antitoxin
I6L53_RS11105 (I6L53_11105) 2372114..2372596 + 483 WP_042319075.1 GNAT family N-acetyltransferase Toxin
I6L53_RS11110 (I6L53_11110) 2372622..2372987 - 366 WP_042319077.1 hypothetical protein -
I6L53_RS11115 (I6L53_11115) 2373079..2373837 + 759 WP_042320028.1 trans-aconitate 2-methyltransferase -
I6L53_RS11120 (I6L53_11120) 2373840..2374316 - 477 WP_042320030.1 CaiF/GrlA family transcriptional regulator -
I6L53_RS11125 (I6L53_11125) 2374580..2377369 - 2790 WP_052425379.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2364826..2372987 8161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17458.34 Da        Isoelectric Point: 9.2027

>T206974 WP_042319075.1 NZ_CP077291:2372114-2372596 [Citrobacter farmeri]
MGIRAPEPLTPGHIVAEFCCSDPGLNEWLRKKALKNHSTGISRVYVICAEETNRVIGYYCLSTGSVQRNTVPGSYRRNAP
ESLPVVVLGRLAVDQSCAGKGLGVALLRDAIFRTENIALQVGVRALIVHALNDDVKSFYMKFAFAPSSINPLTLLYPIKV

Download         Length: 483 bp

>T206974 NZ_CP102833:327277-327645 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10562.05 Da        Isoelectric Point: 4.6722

>AT206974 WP_042319074.1 NZ_CP077291:2371845-2372123 [Citrobacter farmeri]
MKPEAREAPINIRAKTSQRDLIDMAASLVSKSRTDFVLEAACREAQDILLDQRLFILDDKQYDAFLAELDAPITPERQAR
INDLMSRKSPWE

Download         Length: 279 bp

>AT206974 NZ_CP102833:327059-327280 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References