Detailed information of TA system TA206973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2363507..2365092
• Replicon: chromosome
• Accession: NZ_CP077291
• Organism: Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8H9P0X8
• Locus tag: I6L53_RS11060
• Protein ID: WP_042319065.1
• Coordinates: 2363507..2364826 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6L53_RS11065
• Protein ID: WP_042319066.1
• Coordinates: 2364826..2365092 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L53_RS11055 (I6L53_11055)	2361783..2363111	-	1329	WP_042319064.1	glycoside hydrolase family 10 protein	-
I6L53_RS11060 (I6L53_11060)	2363507..2364826	-	1320	WP_042319065.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L53_RS11065 (I6L53_11065)	2364826..2365092	-	267	WP_042319066.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6L53_RS11070 (I6L53_11070)	2365290..2365901	+	612	WP_042319067.1	DJ-1/PfpI family protein	-
I6L53_RS11075 (I6L53_11075)	2365974..2366693	-	720	WP_042319068.1	FadR/GntR family transcriptional regulator	-
I6L53_RS11080 (I6L53_11080)	2366784..2367875	-	1092	WP_174349290.1	L-idonate 5-dehydrogenase	-
I6L53_RS11085 (I6L53_11085)	2367844..2369205	-	1362	WP_042319070.1	MFS transporter	-
I6L53_RS11090 (I6L53_11090)	2369289..2370056	-	768	WP_042319071.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49060.66 Da
• Isoelectric Point: 8.9647

>T206973 WP_042319065.1 NZ_CP077291:c2364826-2363507 [Citrobacter farmeri]
MPKLITWMNNQRVGELTKQANGAHTFKYASDWLANRYARPLSLSLPLQVGKITSDAVFNFFDNLLPDSPIVRDRIVKRYR
AKSKQPFDLLSEVGRDSVGAVTLLSENEAVTNPVMVWEKLSEAKLEEVLSAYKSDIPLGMINEENDFRISVAGAQEKTAL
LRMGNHWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYFCLLLAKQLGLDVPGAEIIKAGRVRALAVERFDRRW
NAERSVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGRKTAVDKIYPRHFMATAKALKFPQEQMREILCKFAEQIP
AALENVTAALPKDFPENVAMAIRSNVLRLHGRLNRETEE

Nucleotide

• Length: 1320 bp

>T206973 NZ_CP102833:200101-200586 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAACCAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9992.43 Da
• Isoelectric Point: 4.6081

>AT206973 WP_042319066.1 NZ_CP077291:c2365092-2364826 [Citrobacter farmeri]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLMTFFKILQSLELSMTLCETKDAAPES
SDQQSLEW

Nucleotide

• Length: 267 bp

>AT206973 NZ_CP102833:199847-200113 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA