Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 5283693..5284302 Replicon chromosome
Accession NC_003272
Organism Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)

Toxin (Protein)


Gene name relE Uniprot ID A0A1Z4KM01
Locus tag PCC7120DELTA_RS23710 Protein ID WP_044522174.1
Coordinates 5283693..5284055 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1Z4KM70
Locus tag PCC7120DELTA_RS23715 Protein ID WP_044523269.1
Coordinates 5284045..5284302 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC7120DELTA_RS23695 5280720..5281358 + 639 WP_010998539.1 peroxiredoxin -
PCC7120DELTA_RS23700 5281498..5282082 + 585 WP_010998540.1 Uma2 family endonuclease -
PCC7120DELTA_RS23705 5282122..5283600 - 1479 WP_044522173.1 NACHT domain-containing protein -
PCC7120DELTA_RS23710 5283693..5284055 - 363 WP_044522174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PCC7120DELTA_RS23715 5284045..5284302 - 258 WP_044523269.1 hypothetical protein Antitoxin
PCC7120DELTA_RS32260 5284415..5284585 - 171 WP_010998544.1 hypothetical protein -
PCC7120DELTA_RS23720 5284691..5285836 - 1146 WP_010998545.1 hypothetical protein -
PCC7120DELTA_RS23725 5285817..5286704 - 888 WP_010998546.1 adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13858.47 Da        Isoelectric Point: 4.9328

>T20697 WP_044522174.1 NC_003272:c5284055-5283693 [Nostoc sp. PCC 7120 = FACHB-418]
MQSDNTVSIRFSDEFEAELYRLSKRFRKIRSDVQPIIEQLQQGDFVGDRISGFGEEYFVYKVRVRNSNIQKGKSAGYRLI
YQVDSPTNIVLLTIYSKSDREDIGANEIRDILADFYGDSG

Download         Length: 363 bp

>T20697 NC_003272:c5284055-5283693 [Nostoc sp. PCC 7120 = FACHB-418]
ATGCAGAGTGACAACACAGTATCAATTCGTTTCTCCGATGAGTTTGAGGCAGAACTTTACAGACTCTCAAAAAGATTCCG
CAAGATTCGCTCTGATGTCCAACCGATTATCGAGCAGTTACAACAAGGGGATTTTGTAGGCGATAGAATTAGCGGATTTG
GGGAAGAATATTTTGTTTACAAGGTGAGAGTTCGCAACAGTAATATCCAAAAAGGTAAAAGTGCTGGATACCGACTGATT
TATCAAGTTGATTCACCCACGAATATTGTGTTGCTAACAATCTATTCTAAATCTGATCGAGAAGATATTGGTGCTAATGA
AATTCGAGATATTCTGGCTGATTTTTATGGTGATTCAGGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9632.83 Da        Isoelectric Point: 4.0373

>AT20697 WP_044523269.1 NC_003272:c5284302-5284045 [Nostoc sp. PCC 7120 = FACHB-418]
MKAIEVTGKIDAQGNLILDQPIQGTTYPDQVRVIVLIPEQEETEEFDPDDTPVEEIKASLRRALQQAKMGQTRPISELWD
RIDAE

Download         Length: 258 bp

>AT20697 NC_003272:c5284302-5284045 [Nostoc sp. PCC 7120 = FACHB-418]
ATGAAAGCGATCGAAGTAACTGGCAAAATAGATGCTCAAGGAAATTTAATTTTAGATCAGCCGATTCAGGGAACAACTTA
CCCTGATCAAGTACGGGTGATTGTGTTAATTCCAGAACAGGAAGAAACAGAAGAGTTTGACCCAGACGATACACCAGTTG
AGGAAATTAAAGCCAGCTTGAGGAGAGCCTTACAGCAAGCAAAGATGGGTCAAACAAGACCAATTAGTGAGCTATGGGAC
AGAATTGATGCAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z4KM01

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z4KM70

References