Detailed information of TA system TA206961

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 794943..795597
• Replicon: chromosome
• Accession: NZ_CP077291
• Organism: Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8H9NUQ3
• Locus tag: I6L53_RS03735
• Protein ID: WP_042322126.1
• Coordinates: 795190..795597 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0F6TWP9
• Locus tag: I6L53_RS03730
• Protein ID: WP_042322123.1
• Coordinates: 794943..795209 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L53_RS03705 (I6L53_03705)	790125..791558	-	1434	WP_042322113.1	6-phospho-beta-glucosidase BglA	-
I6L53_RS03710 (I6L53_03710)	791678..792406	-	729	WP_042322114.1	MurR/RpiR family transcriptional regulator	-
I6L53_RS03715 (I6L53_03715)	792459..792770	+	312	WP_042322117.1	N(4)-acetylcytidine aminohydrolase	-
I6L53_RS03720 (I6L53_03720)	792933..793592	+	660	WP_042322119.1	hemolysin III family protein	-
I6L53_RS03725 (I6L53_03725)	793706..794686	-	981	WP_042322121.1	tRNA-modifying protein YgfZ	-
I6L53_RS03730 (I6L53_03730)	794943..795209	+	267	WP_042322123.1	FAD assembly factor SdhE	Antitoxin
I6L53_RS03735 (I6L53_03735)	795190..795597	+	408	WP_042322126.1	protein YgfX	Toxin
I6L53_RS03740 (I6L53_03740)	795676..796197	-	522	WP_042322127.1	flavodoxin FldB	-
I6L53_RS03745 (I6L53_03745)	796298..797194	+	897	WP_042322732.1	site-specific tyrosine recombinase XerD	-
I6L53_RS03750 (I6L53_03750)	797218..797931	+	714	WP_042322130.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
I6L53_RS03755 (I6L53_03755)	797937..799670	+	1734	WP_042322132.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15880.89 Da
• Isoelectric Point: 11.3523

>T206961 WP_042322126.1 NZ_CP077291:795190-795597 [Citrobacter farmeri]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDEAEWRDLRRLMMQKSTLG

Nucleotide

• Length: 408 bp

>T206961 NZ_CP102827:c2332091-2331807 [Salmonella enterica subsp. enterica serovar Indiana]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGGAACGACTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.06 Da
• Isoelectric Point: 5.1496

>AT206961 WP_042322123.1 NZ_CP077291:794943-795209 [Citrobacter farmeri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Nucleotide

• Length: 267 bp

>AT206961 NZ_CP102827:c2332329-2332081 [Salmonella enterica subsp. enterica serovar Indiana]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0F6TWP9