Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 153305..153930 Replicon chromosome
Accession NZ_CP077291
Organism Citrobacter farmeri strain FDAARGOS 1423

Toxin (Protein)


Gene name vapC Uniprot ID A0A8H9NYB7
Locus tag I6L53_RS00735 Protein ID WP_042325461.1
Coordinates 153544..153930 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6L53_RS00730 Protein ID WP_225935005.1
Coordinates 153305..153544 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L53_RS00705 (I6L53_00705) 149260..149859 + 600 WP_042325450.1 glucose-1-phosphatase -
I6L53_RS00710 (I6L53_00710) 149853..150725 + 873 WP_042325452.1 virulence factor BrkB family protein -
I6L53_RS00715 (I6L53_00715) 150722..151159 + 438 WP_042325454.1 D-aminoacyl-tRNA deacylase -
I6L53_RS00720 (I6L53_00720) 151204..152145 + 942 WP_042325456.1 fatty acid biosynthesis protein FabY -
I6L53_RS00725 (I6L53_00725) 152162..153094 - 933 WP_042325458.1 alpha/beta hydrolase -
I6L53_RS00730 (I6L53_00730) 153305..153544 + 240 WP_225935005.1 CopG family transcriptional regulator Antitoxin
I6L53_RS00735 (I6L53_00735) 153544..153930 + 387 WP_042325461.1 type II toxin-antitoxin system VapC family toxin Toxin
I6L53_RS00740 (I6L53_00740) 153961..154890 - 930 WP_042325463.1 formate dehydrogenase accessory protein FdhE -
I6L53_RS00745 (I6L53_00745) 155035..155721 - 687 WP_042325465.1 response regulator transcription factor -
I6L53_RS00750 (I6L53_00750) 155726..157222 - 1497 WP_042325467.1 HAMP domain-containing sensor histidine kinase -
I6L53_RS00755 (I6L53_00755) 157240..158577 - 1338 WP_072015778.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14533.90 Da        Isoelectric Point: 10.0929

>T206959 WP_042325461.1 NZ_CP077291:153544-153930 [Citrobacter farmeri]
MHKKPVLFDTNILIDLFSGHQEAQRALEAFPPQNAISLITWMEVMVGAKKYHQEYRTRVALSAFNIIGVSPEIAERSVNL
RQEYKMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQTGR

Download         Length: 387 bp

>T206959 NZ_CP102827:c1116994-1116743 [Salmonella enterica subsp. enterica serovar Indiana]
ATGCGGGATACTTACAAAACCCACATGACCACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGC
AGAAGCGGGATTTGATACCGGGGCGAGCGTGACCGTGAAGATCTCCGAAGGGTGTTTGACTCTGATTGTGGAGACAGACG
AAGTGAGGGATCTACGGAGGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCACATTAAGGCGGGGGTATATGATGTGGTG
AACGGGAATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9181.41 Da        Isoelectric Point: 4.2075

>AT206959 WP_225935005.1 NZ_CP077291:153305-153544 [Citrobacter farmeri]
MAGMDMGRILLDLSDEAIKRLDDLKQLRNLPRAELLREAVEQYLERQGQAETMISNALGIWQGCEEDGVEYQKTLREEW

Download         Length: 240 bp

>AT206959 NZ_CP102827:1116753-1116978 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References