206950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4151716..4152314 Replicon chromosome
Accession NZ_CP077290
Organism Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag I6L58_RS19605 Protein ID WP_088207983.1
Coordinates 4151934..4152314 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag I6L58_RS19600 Protein ID WP_088207982.1
Coordinates 4151716..4151937 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L58_RS19580 (I6L58_19580) 4147716..4148939 + 1224 WP_006176577.1 alanine transaminase -
I6L58_RS19585 (I6L58_19585) 4148996..4149067 - 72 WP_099458937.1 membrane protein YpdK -
I6L58_RS19590 (I6L58_19590) 4149425..4150342 - 918 WP_042320354.1 kdo(2)-lipid IV(A) palmitoleoyltransferase -
I6L58_RS19595 (I6L58_19595) 4150718..4151398 + 681 WP_088207981.1 helix-turn-helix domain-containing protein -
I6L58_RS19600 (I6L58_19600) 4151716..4151937 + 222 WP_088207982.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6L58_RS19605 (I6L58_19605) 4151934..4152314 + 381 WP_088207983.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6L58_RS19610 (I6L58_19610) 4152624..4153172 - 549 WP_254082132.1 tyrosine-type recombinase/integrase -
I6L58_RS19620 (I6L58_19620) 4153536..4154465 - 930 WP_088207984.1 formate/nitrite transporter family protein -
I6L58_RS19625 (I6L58_19625) 4154782..4155534 + 753 WP_006176573.1 phospholipid-binding lipoprotein MlaA -
I6L58_RS19630 (I6L58_19630) 4155580..4156908 - 1329 WP_058610259.1 long-chain fatty acid transporter FadL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14082.14 Da        Isoelectric Point: 6.7268

>T206950 WP_088207983.1 NZ_CP077290:4151934-4152314 [Enterobacter cancerogenus]
MKWISAQEVIAFHDRILRYLPGVAGMPDAGKADAIIYRVQNRAHYEGVNNIFELAATYWVAIARGHIFNDGNKRTSFFVT
MAFLRRNGVLVLDEGTELEELTVQAATGEKTVEQLSAILRTLAIQS

Download         Length: 381 bp

>T206950 NZ_CP102821:3861-4148 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8051.01 Da        Isoelectric Point: 5.0190

>AT206950 WP_088207982.1 NZ_CP077290:4151716-4151937 [Enterobacter cancerogenus]
MITYTSTQARANISAVLESATSGEPVEITRRDGSAAVVISKAEFEAYQAAKLDDEFDFIMQRHGRTIKALTDR

Download         Length: 222 bp

>AT206950 NZ_CP102821:4135-4449 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References