Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2190767..2191212 Replicon chromosome
Accession NC_003272
Organism Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120)

Toxin (Protein)


Gene name hicA Uniprot ID Q8YVZ2
Locus tag PCC7120DELTA_RS10895 Protein ID WP_010995992.1
Coordinates 2190767..2190994 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID Q8YVZ1
Locus tag PCC7120DELTA_RS10900 Protein ID WP_010995993.1
Coordinates 2190994..2191212 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC7120DELTA_RS10880 2188125..2188706 + 582 WP_010995989.1 Uma2 family endonuclease -
PCC7120DELTA_RS10885 2188887..2189321 + 435 WP_010995990.1 DUF2809 domain-containing protein -
PCC7120DELTA_RS10890 2189616..2190716 - 1101 WP_010995991.1 ABC transporter ATP-binding protein -
PCC7120DELTA_RS10895 2190767..2190994 - 228 WP_010995992.1 type II toxin-antitoxin system HicA family toxin Toxin
PCC7120DELTA_RS10900 2190994..2191212 - 219 WP_010995993.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCC7120DELTA_RS10905 2191287..2192003 - 717 WP_010995994.1 GUN4 domain-containing protein -
PCC7120DELTA_RS10910 2192333..2193754 + 1422 WP_010995995.1 NADP-dependent isocitrate dehydrogenase -
PCC7120DELTA_RS10915 2193881..2194144 + 264 WP_010995996.1 hypothetical protein -
PCC7120DELTA_RS10920 2194148..2194543 - 396 WP_010995997.1 hypothetical protein -
PCC7120DELTA_RS10925 2194556..2194864 - 309 WP_010995998.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(9-64)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8415.86 Da        Isoelectric Point: 10.4807

>T20695 WP_010995992.1 NC_003272:c2190994-2190767 [Nostoc sp. PCC 7120 = FACHB-418]
MPKLPGLTGKKVINTLEKLGFQVVRQRGSHVQMEHDDGRLVTVPVHAGKTIGRGWLSKILRDAELTREEFIALLE

Download         Length: 228 bp

>T20695 NC_003272:c2190994-2190767 [Nostoc sp. PCC 7120 = FACHB-418]
ATGCCGAAATTACCAGGTTTAACTGGAAAAAAAGTTATTAATACCCTTGAGAAATTAGGATTTCAAGTGGTGCGTCAACG
AGGTAGTCACGTACAAATGGAACATGATGACGGTCGTTTAGTCACTGTTCCTGTTCATGCTGGTAAAACAATAGGTAGAG
GGTGGCTCAGTAAAATATTACGCGATGCTGAACTTACAAGAGAAGAGTTTATCGCATTGCTGGAATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8322.45 Da        Isoelectric Point: 3.9610

>AT20695 WP_010995993.1 NC_003272:c2191212-2190994 [Nostoc sp. PCC 7120 = FACHB-418]
MSNATKREFYVIIERDDDGYYVGEVPQLKGCYSQGETIDELMINMKEVIELCLETETDENKPEFIGIQKVVI

Download         Length: 219 bp

>AT20695 NC_003272:c2191212-2190994 [Nostoc sp. PCC 7120 = FACHB-418]
ATGAGTAATGCTACTAAACGAGAATTTTACGTCATCATTGAACGGGATGATGATGGGTATTATGTGGGAGAAGTTCCCCA
ACTAAAAGGCTGTTATAGCCAAGGAGAAACCATTGATGAACTAATGATAAATATGAAAGAAGTAATCGAACTATGTTTAG
AAACTGAAACTGATGAAAATAAACCAGAATTTATCGGTATTCAAAAGGTAGTGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8YVZ2

Antitoxin

Source ID Structure
AlphaFold DB Q8YVZ1

References