Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3621261..3621918 | Replicon | chromosome |
Accession | NZ_CP077290 | ||
Organism | Enterobacter cancerogenus strain FDAARGOS 1428 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A5Q2KE30 |
Locus tag | I6L58_RS17095 | Protein ID | WP_058608592.1 |
Coordinates | 3621508..3621918 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W7NX65 |
Locus tag | I6L58_RS17090 | Protein ID | WP_006178375.1 |
Coordinates | 3621261..3621527 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6L58_RS17070 (I6L58_17070) | 3616680..3618113 | - | 1434 | WP_058608594.1 | 6-phospho-beta-glucosidase | - |
I6L58_RS17075 (I6L58_17075) | 3618229..3618960 | - | 732 | WP_088208682.1 | MurR/RpiR family transcriptional regulator | - |
I6L58_RS17080 (I6L58_17080) | 3619227..3619886 | + | 660 | WP_006178378.1 | hemolysin III family protein | - |
I6L58_RS17085 (I6L58_17085) | 3619986..3620966 | - | 981 | WP_088208586.1 | tRNA-modifying protein YgfZ | - |
I6L58_RS17090 (I6L58_17090) | 3621261..3621527 | + | 267 | WP_006178375.1 | FAD assembly factor SdhE | Antitoxin |
I6L58_RS17095 (I6L58_17095) | 3621508..3621918 | + | 411 | WP_058608592.1 | protein YgfX | Toxin |
I6L58_RS17100 (I6L58_17100) | 3621926..3622447 | - | 522 | WP_006178373.1 | flavodoxin FldB | - |
I6L58_RS17105 (I6L58_17105) | 3622549..3623445 | + | 897 | WP_006178372.1 | site-specific tyrosine recombinase XerD | - |
I6L58_RS17110 (I6L58_17110) | 3623474..3624187 | + | 714 | WP_006178371.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
I6L58_RS17115 (I6L58_17115) | 3624193..3625926 | + | 1734 | WP_088208587.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16190.97 Da Isoelectric Point: 11.1724
>T206949 WP_058608592.1 NZ_CP077290:3621508-3621918 [Enterobacter cancerogenus]
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD
Download Length: 411 bp
>T206949 NZ_CP102820:c34431-34072 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10569.05 Da Isoelectric Point: 5.1340
>AT206949 WP_006178375.1 NZ_CP077290:3621261-3621527 [Enterobacter cancerogenus]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI
Download Length: 267 bp
>AT206949 NZ_CP102820:c34072-33773 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAAACTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAAACTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Q2KE30 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | W7NX65 |