206949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3621261..3621918 Replicon chromosome
Accession NZ_CP077290
Organism Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)


Gene name cptA Uniprot ID A0A5Q2KE30
Locus tag I6L58_RS17095 Protein ID WP_058608592.1
Coordinates 3621508..3621918 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag I6L58_RS17090 Protein ID WP_006178375.1
Coordinates 3621261..3621527 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L58_RS17070 (I6L58_17070) 3616680..3618113 - 1434 WP_058608594.1 6-phospho-beta-glucosidase -
I6L58_RS17075 (I6L58_17075) 3618229..3618960 - 732 WP_088208682.1 MurR/RpiR family transcriptional regulator -
I6L58_RS17080 (I6L58_17080) 3619227..3619886 + 660 WP_006178378.1 hemolysin III family protein -
I6L58_RS17085 (I6L58_17085) 3619986..3620966 - 981 WP_088208586.1 tRNA-modifying protein YgfZ -
I6L58_RS17090 (I6L58_17090) 3621261..3621527 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
I6L58_RS17095 (I6L58_17095) 3621508..3621918 + 411 WP_058608592.1 protein YgfX Toxin
I6L58_RS17100 (I6L58_17100) 3621926..3622447 - 522 WP_006178373.1 flavodoxin FldB -
I6L58_RS17105 (I6L58_17105) 3622549..3623445 + 897 WP_006178372.1 site-specific tyrosine recombinase XerD -
I6L58_RS17110 (I6L58_17110) 3623474..3624187 + 714 WP_006178371.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L58_RS17115 (I6L58_17115) 3624193..3625926 + 1734 WP_088208587.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16190.97 Da        Isoelectric Point: 11.1724

>T206949 WP_058608592.1 NZ_CP077290:3621508-3621918 [Enterobacter cancerogenus]
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD

Download         Length: 411 bp

>T206949 NZ_CP102820:c34431-34072 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT206949 WP_006178375.1 NZ_CP077290:3621261-3621527 [Enterobacter cancerogenus]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206949 NZ_CP102820:c34072-33773 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAAACTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5Q2KE30


Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References