Detailed information of TA system TA206947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2619945..2620606
• Replicon: chromosome
• Accession: NZ_CP077290
• Organism: Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D2ZIF7
• Locus tag: I6L58_RS12340
• Protein ID: WP_006177650.1
• Coordinates: 2619945..2620343 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I6L58_RS12345
• Protein ID: WP_088208961.1
• Coordinates: 2620340..2620606 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L58_RS12315 (I6L58_12315)	2615315..2616379	+	1065	WP_006177656.1	fimbrial protein	-
I6L58_RS12320 (I6L58_12320)	2616420..2616965	-	546	WP_241493789.1	LuxR C-terminal-related transcriptional regulator	-
I6L58_RS12325 (I6L58_12325)	2617628..2618248	+	621	WP_042321296.1	LuxR C-terminal-related transcriptional regulator	-
I6L58_RS12330 (I6L58_12330)	2618324..2619004	+	681	WP_088208963.1	EAL domain-containing protein	-
I6L58_RS12335 (I6L58_12335)	2619010..2619810	-	801	WP_088208962.1	lipoprotein NlpA	-
I6L58_RS12340 (I6L58_12340)	2619945..2620343	-	399	WP_006177650.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6L58_RS12345 (I6L58_12345)	2620340..2620606	-	267	WP_088208961.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
I6L58_RS12350 (I6L58_12350)	2620718..2622211	-	1494	WP_088208960.1	MDR family MFS transporter	-
I6L58_RS12355 (I6L58_12355)	2622305..2622952	+	648	WP_088208959.1	TetR/AcrR family transcriptional regulator	-
I6L58_RS12360 (I6L58_12360)	2622949..2623368	-	420	WP_088208958.1	GNAT family N-acetyltransferase	-
I6L58_RS12365 (I6L58_12365)	2623551..2624120	+	570	WP_088208957.1	TetR/AcrR family transcriptional regulator	-
I6L58_RS12370 (I6L58_12370)	2624268..2625389	+	1122	WP_088208956.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14606.72 Da
• Isoelectric Point: 5.9718

>T206947 WP_006177650.1 NZ_CP077290:c2620343-2619945 [Enterobacter cancerogenus]
MRHMLDTNIVSHLFKRHPGVINRMACLTPDDVCISSITEAELLYGADKKQSERLKKTIQAFLSTITVCDWDSEAAATYGA
LRAAMEKRGNVMGDLDQLIAAHAISQGTTIVTNDRAFLMVQELSVEDWTHAA

Nucleotide

• Length: 399 bp

>T206947 NZ_CP102817:15454-15813 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10185.36 Da
• Isoelectric Point: 6.3656

>AT206947 WP_088208961.1 NZ_CP077290:c2620606-2620340 [Enterobacter cancerogenus]
MERKAKLFKRGRSQAVMLPAEFTFDAESVYIRRDDDGNVVLSEKSASTRSWDNFFRLLENTSVPENFLSKEERNQSITRR
DPLDGVQG

Nucleotide

• Length: 267 bp

>AT206947 NZ_CP102817:15813-16112 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Toxin

• AlphaFold DB: D2ZIF7