Detailed information of TA system TA206946

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2090458..2091138
• Replicon: chromosome
• Accession: NZ_CP077290
• Organism: Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6L58_RS09795
• Protein ID: WP_176399440.1
• Coordinates: 2090458..2090772 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6L58_RS09800
• Protein ID: WP_088208765.1
• Coordinates: 2090815..2091138 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L58_RS09780 (I6L58_09780)	2088098..2089048	-	951	WP_088208769.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I6L58_RS09785 (I6L58_09785)	2089041..2089436	-	396	WP_088208768.1	DUF6088 family protein	-
I6L58_RS09790 (I6L58_09790)	2089511..2090344	-	834	WP_088208767.1	DUF4942 domain-containing protein	-
I6L58_RS09795 (I6L58_09795)	2090458..2090772	-	315	WP_176399440.1	TA system toxin CbtA family protein	Toxin
I6L58_RS09800 (I6L58_09800)	2090815..2091138	-	324	WP_088208765.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6L58_RS09805 (I6L58_09805)	2091151..2091621	-	471	WP_088208764.1	DNA repair protein RadC	-
I6L58_RS09810 (I6L58_09810)	2091692..2092513	-	822	WP_088208763.1	DUF932 domain-containing protein	-
I6L58_RS09815 (I6L58_09815)	2092623..2093033	-	411	WP_230586359.1	IrmA family protein	-
I6L58_RS09820 (I6L58_09820)	2093216..2093863	-	648	WP_043018271.1	hypothetical protein	-
I6L58_RS09825 (I6L58_09825)	2093869..2094570	-	702	WP_088208762.1	WYL domain-containing protein	-
I6L58_RS09830 (I6L58_09830)	2094783..2095658	-	876	WP_088208761.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2066839..2111832	44993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (9-103)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11756.26 Da
• Isoelectric Point: 5.0221

>T206946 WP_176399440.1 NZ_CP077290:c2090772-2090458 [Enterobacter cancerogenus]
ISTVPAKVPVSSRPSPVQVWQQLLTYLLDHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRQGFSW
QEQTPFLTATDILRARRATGLINT

Nucleotide

• Length: 315 bp

>T206946 NZ_CP102816:3861-4148 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12046.84 Da
• Isoelectric Point: 6.7057

>AT206946 WP_088208765.1 NZ_CP077290:c2091138-2090815 [Enterobacter cancerogenus]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPMHLQKLDLAFPLFVEQLEDMLRAGELNPHQQRQVK
IQLASLTCIADPRGSCGYVYISIYPTP

Nucleotide

• Length: 324 bp

>AT206946 NZ_CP102816:4135-4449 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA