Detailed information of TA system TA206945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 2088098..2089436
• Replicon: chromosome
• Accession: NZ_CP077290
• Organism: Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: I6L58_RS09780
• Protein ID: WP_088208769.1
• Coordinates: 2088098..2089048 (-)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: I6L58_RS09785
• Protein ID: WP_088208768.1
• Coordinates: 2089041..2089436 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L58_RS09770 (I6L58_09770)	2083860..2085209	-	1350	WP_088208771.1	DNA phosphorothioation-dependent restriction protein DptG	-
I6L58_RS09775 (I6L58_09775)	2085206..2086816	-	1611	WP_174951949.1	DNA phosphorothioation-dependent restriction protein DptF	-
I6L58_RS09780 (I6L58_09780)	2088098..2089048	-	951	WP_088208769.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6L58_RS09785 (I6L58_09785)	2089041..2089436	-	396	WP_088208768.1	DUF6088 family protein	Antitoxin
I6L58_RS09790 (I6L58_09790)	2089511..2090344	-	834	WP_088208767.1	DUF4942 domain-containing protein	-
I6L58_RS09795 (I6L58_09795)	2090458..2090772	-	315	WP_176399440.1	TA system toxin CbtA family protein	-
I6L58_RS09800 (I6L58_09800)	2090815..2091138	-	324	WP_088208765.1	type IV toxin-antitoxin system YeeU family antitoxin	-
I6L58_RS09805 (I6L58_09805)	2091151..2091621	-	471	WP_088208764.1	DNA repair protein RadC	-
I6L58_RS09810 (I6L58_09810)	2091692..2092513	-	822	WP_088208763.1	DUF932 domain-containing protein	-
I6L58_RS09815 (I6L58_09815)	2092623..2093033	-	411	WP_230586359.1	IrmA family protein	-
I6L58_RS09820 (I6L58_09820)	2093216..2093863	-	648	WP_043018271.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2066839..2111832	44993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-304)

Antitoxin

• Protein of unknown function DUF6088 (7-126)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 35911.37 Da
• Isoelectric Point: 4.7441

>T206945 WP_088208769.1 NZ_CP077290:c2089048-2088098 [Enterobacter cancerogenus]
MADLIKLFPDVADALGIESVAIVEKDYYIVELLRLLQPLAFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGISQ
QYSRGKRKSIRKGIIQTIIETIAASDTFRMDEEYPKVTRDEYRYNEIPVRYPQEYAQIPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASVRNVERAVDESLVRHIYDNFCIVREKGADVPVLKRFV
QECIEQDIQRYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESHVSWEEAYACFRITALDVIDA

Nucleotide

• Length: 951 bp

>T206945 NZ_CP102815:3861-4148 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14439.83 Da
• Isoelectric Point: 11.0360

>AT206945 WP_088208768.1 NZ_CP077290:c2089436-2089041 [Enterobacter cancerogenus]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELMKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPALVEIKTSPRFKRTLSVGNSKLNG

Nucleotide

• Length: 396 bp

>AT206945 NZ_CP102815:4135-4449 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA