Detailed information of TA system TA206944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-KacA/DUF1778(antitoxin)
• Location: 2047078..2047872
• Replicon: chromosome
• Accession: NZ_CP077290
• Organism: Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: D2ZA23
• Locus tag: I6L58_RS09605
• Protein ID: WP_006174149.1
• Coordinates: 2047351..2047872 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: KacA
• Uniprot ID: D2ZA22
• Locus tag: I6L58_RS09600
• Protein ID: WP_006174147.1
• Coordinates: 2047078..2047347 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L58_RS09580 (I6L58_09580)	2042868..2044166	+	1299	WP_088208798.1	DUF445 domain-containing protein	-
I6L58_RS09585 (I6L58_09585)	2044136..2045212	-	1077	WP_088208797.1	DUF2955 domain-containing protein	-
I6L58_RS09590 (I6L58_09590)	2045202..2046269	-	1068	WP_088208796.1	HlyD family secretion protein	-
I6L58_RS09595 (I6L58_09595)	2046266..2046736	-	471	WP_058609602.1	MarR family transcriptional regulator	-
I6L58_RS09600 (I6L58_09600)	2047078..2047347	+	270	WP_006174147.1	DUF1778 domain-containing protein	Antitoxin
I6L58_RS09605 (I6L58_09605)	2047351..2047872	+	522	WP_006174149.1	GNAT family N-acetyltransferase	Toxin
I6L58_RS09610 (I6L58_09610)	2047925..2049340	-	1416	WP_088208795.1	aldehyde dehydrogenase family protein	-
I6L58_RS09615 (I6L58_09615)	2049441..2050343	+	903	WP_088208794.1	LysR family transcriptional regulator	-
I6L58_RS09620 (I6L58_09620)	2050330..2050809	-	480	WP_006174154.1	carboxymuconolactone decarboxylase family protein	-
I6L58_RS09625 (I6L58_09625)	2050911..2052299	+	1389	WP_088208793.1	PLP-dependent aminotransferase family protein	-
I6L58_RS09630 (I6L58_09630)	2052384..2052545	-	162	WP_058609595.1	DUF1127 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 19728.67 Da
• Isoelectric Point: 7.3189

>T206944 WP_006174149.1 NZ_CP077290:2047351-2047872 [Enterobacter cancerogenus]
VNDVKIGIFSEDVEYDLSQFDCGEVSLNTFLAEHLKRQHRGKFLRAYVLTTREENPRVLGYYTLSGSCFEKAYLPSKTQQ
KRIPYKNVPSVTLGRLAIDKRIQGQGFGELLVTHAMKTVYLASFAVGIHGLFVEALNDTARNFYLKLGFIPLLAENEFTL
FLPTKTFESMFEE

Nucleotide

• Length: 522 bp

>T206944 NZ_CP102814:3861-4148 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10142.57 Da
• Isoelectric Point: 7.0164

>AT206944 WP_006174147.1 NZ_CP077290:2047078-2047347 [Enterobacter cancerogenus]
MTALKKQRIDLRLSEDDKSLIEEAAAMTNQSISQFMVSTASERAAEVIDRHRRMILNEASWNTVMEAISNPPAPNDRLKR
AAKRLQDME

Nucleotide

• Length: 270 bp

>AT206944 NZ_CP102814:4135-4449 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Toxin

• AlphaFold DB: D2ZA23

Antitoxin

• AlphaFold DB: D2ZA22