Detailed information of TA system TA206943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1560431..1561051
• Replicon: chromosome
• Accession: NZ_CP077290
• Organism: Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: D2ZG55
• Locus tag: I6L58_RS07375
• Protein ID: WP_006176938.1
• Coordinates: 1560833..1561051 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: D2ZG56
• Locus tag: I6L58_RS07370
• Protein ID: WP_006176939.1
• Coordinates: 1560431..1560805 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L58_RS07360 (I6L58_07360)	1555558..1556751	+	1194	WP_088207829.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
I6L58_RS07365 (I6L58_07365)	1556774..1559920	+	3147	WP_088207830.1	multidrug efflux RND transporter permease subunit AcrB	-
I6L58_RS07370 (I6L58_07370)	1560431..1560805	+	375	WP_006176939.1	Hha toxicity modulator TomB	Antitoxin
I6L58_RS07375 (I6L58_07375)	1560833..1561051	+	219	WP_006176938.1	HHA domain-containing protein	Toxin
I6L58_RS07380 (I6L58_07380)	1561257..1561808	+	552	WP_088207831.1	maltose O-acetyltransferase	-
I6L58_RS07385 (I6L58_07385)	1561925..1562413	+	489	WP_042320836.1	YlaC family protein	-
I6L58_RS07390 (I6L58_07390)	1562364..1563824	-	1461	WP_088207832.1	PLP-dependent aminotransferase family protein	-
I6L58_RS07395 (I6L58_07395)	1563926..1564636	+	711	WP_088207919.1	GNAT family protein	-
I6L58_RS07400 (I6L58_07400)	1564633..1564773	-	141	WP_003859006.1	type B 50S ribosomal protein L36	-
I6L58_RS07405 (I6L58_07405)	1564776..1565036	-	261	WP_006176933.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8612.00 Da
• Isoelectric Point: 8.9008

>T206943 WP_006176938.1 NZ_CP077290:1560833-1561051 [Enterobacter cancerogenus]
MSEKPLTKIDYLMRLRRCQSLDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Nucleotide

• Length: 219 bp

>T206943 NZ_CP102780:5735101-5735391 [Pandoraea commovens]
TTGACGACTTATGACCTGCAATTTCTCCCTTCTGCGCTCAAGGAATGGCAGGCTCTCGACGCCTCGATCCAACGCCAGTT
CAAGACAAAACTGCGCAGGCGCTTACAGCAACCGCAGGTGCCTGGCAGTCGATTGAAGGCCATGCCCGACTGCTACAAGA
TCAAACTTGCCTCAGCGGGCTATCGACTTATCTATCGAGTCAATGAATCAGCCATCACCGTGCTGGTCGTGGCCGTAGGG
AAACGAGAGAACCTCAAGGTCTACCGCAACGCCAGTGAGCGATTGACATAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14467.25 Da
• Isoelectric Point: 4.8886

>AT206943 WP_006176939.1 NZ_CP077290:1560431-1560805 [Enterobacter cancerogenus]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINASRANPVSLSC

Nucleotide

• Length: 375 bp

>AT206943 NZ_CP102780:5734872-5735114 [Pandoraea commovens]
ATGAAAATCATCCTTGCCAGCGCATCGATCGGAATCAGCGAATTGAAATCAAACCCCAGCGCCGCCATCAACCGTGCCAA
CGGTCCCGTCGCCATCCTGAATCGCAACACGCCGGTGGCATATCTCATTCCCGCCGCGGATTGGGAAACGATCTGCGAAC
GCCTGGACGACGCCGACCTCGCCGACATCATCCGTTCACGCGCCGGTGAAACGCCGGTGAGTACGAAGCTTGACGACTTA
TGA

Structures

Toxin

• AlphaFold DB: D2ZG55

Antitoxin

• AlphaFold DB: D2ZG56