Detailed information of TA system TA206942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 333650..335226
• Replicon: chromosome
• Accession: NZ_CP077290
• Organism: Enterobacter cancerogenus strain FDAARGOS 1428

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L58_RS01555
• Protein ID: WP_088209102.1
• Coordinates: 333650..334969 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6L58_RS01560
• Protein ID: WP_088209101.1
• Coordinates: 334969..335226 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L58_RS01540 (I6L58_01540)	329862..330767	+	906	WP_088209105.1	LysR family transcriptional regulator	-
I6L58_RS01545 (I6L58_01545)	331004..331369	+	366	WP_088209104.1	hypothetical protein	-
I6L58_RS01550 (I6L58_01550)	331380..333491	+	2112	WP_088209103.1	pyrroloquinoline quinone-dependent dehydrogenase	-
I6L58_RS01555 (I6L58_01555)	333650..334969	-	1320	WP_088209102.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L58_RS01560 (I6L58_01560)	334969..335226	-	258	WP_088209101.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6L58_RS01565 (I6L58_01565)	335344..336102	-	759	WP_088209100.1	DeoR/GlpR family DNA-binding transcription regulator	-
I6L58_RS01570 (I6L58_01570)	336189..336773	+	585	WP_006175284.1	hydrolase YffH	-
I6L58_RS01575 (I6L58_01575)	336860..337618	+	759	WP_088209099.1	trans-aconitate 2-methyltransferase	-
I6L58_RS01580 (I6L58_01580)	337627..338817	-	1191	WP_088209098.1	cytochrome c biogenesis protein/redoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-68)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 48840.16 Da
• Isoelectric Point: 7.4817

>T206942 WP_088209102.1 NZ_CP077290:c334969-333650 [Enterobacter cancerogenus]
MPTLVTWMNNERVGELTKLPTGAHTYRYDKTWLSSPYARPLSLSLPLQTGNITSDAVFNFFDNLLPDSPVVRDRIVKRYQ
AKSKQPFDLLSEIGRDSVGAVTLLPPEEASLNPVMAWETLSEQKLEAILSAYKSDIPLGMIDDENDFRISVAGAQEKTAL
LKKGDDWCIPKGTTPTTHIIKLPIGEIRQPNATLDLRDSVDNEYFCLKFANALGFEVPKAEIINAGRVRALAVERFDRRW
NADHTVLLRLPQEDMCQTFGLPSSLKYESDGGPGIAQIMSFLLGSSAALKDRHNFMKFQVFQWLLGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLTATRGRKNAIDKIHPRHFMATAKAVKFPEDRMREIMQSFADHVP
LALNEVMDSLPEGFCDKVATSITSNVLRLHARLCKEVGK

Nucleotide

• Length: 1320 bp

>T206942 NZ_CP102780:c4100335-4100057 [Pandoraea commovens]
TTGATTGAAAATTTCAAATGCAGGGATACGGCACTGCTGTTCAGCGGGCGTCGCGTGATGCGCTGGCGTGCGGTCGAGTC
GGCCGCTATGCGTAAGCTTCAGCAACTCCATGCGGCGGCCACACTGAGTTTCTTACGCGCGCCACCGGGTAACAGACTTG
AAGCGCTGCGCGGAAATCGTCTGGGACAGTACAGCATTCGGATCAACGACCAGTGGCGGTTGTGTTTCCGTTTTGACGCG
GGCACCGCTTCCGACGTCGAAATCGTCGACTACCACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9592.90 Da
• Isoelectric Point: 6.4571

>AT206942 WP_088209101.1 NZ_CP077290:c335226-334969 [Enterobacter cancerogenus]
MKASMIYSPTQLANAMRLVRQKNNWTQSELAKKIGIKQATISNFENAPDNTTLATFFKILQSLEMSVSLHEADHAVADNP
QELDW

Nucleotide

• Length: 258 bp

>AT206942 NZ_CP102780:c4099982-4099671 [Pandoraea commovens]
ATGACCCGACAAGTACCATTGGCAACACCGGGCGAGATTCTCGCGCAAGAGTGGCTCGGCCCGATGGGCATCTCGCAATA
CGCACTGGCTAAAGCCATTGATGTGCCCCCTCGCCGGATCAATGAGATCGTGCTCGGCAAACGGGCGATTACCGTCGATA
CCGCACTGCGTTTAGGGGCGTTCTTTGGCGTGGATGCGCAGAGCTGGCTCAATCTCCAAAATCAGTACGATGCTGAAATC
GCGCGCGCGAACATGGTCGATGTTCTGAAGACGATCAAGCACCGAGCACGGGCGTTGCTCGCAGCCGCATGA