Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4388145..4388802 Replicon chromosome
Accession NZ_CP077279
Organism Klebsiella quasipneumoniae strain FDAARGOS 1443

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag I6L73_RS21030 Protein ID WP_004205323.1
Coordinates 4388145..4388555 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6L73_RS21035 Protein ID WP_002916312.1
Coordinates 4388536..4388802 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L73_RS21010 (4384145) 4384145..4385878 - 1734 WP_136084845.1 single-stranded-DNA-specific exonuclease RecJ -
I6L73_RS21015 (4385884) 4385884..4386597 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L73_RS21020 (4386620) 4386620..4387516 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6L73_RS21025 (4387617) 4387617..4388138 + 522 WP_004205324.1 flavodoxin FldB -
I6L73_RS21030 (4388145) 4388145..4388555 - 411 WP_004205323.1 protein YgfX Toxin
I6L73_RS21035 (4388536) 4388536..4388802 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6L73_RS21040 (4389048) 4389048..4390031 + 984 WP_017899798.1 tRNA-modifying protein YgfZ -
I6L73_RS21045 (4390130) 4390130..4390789 - 660 WP_004205319.1 hemolysin III family protein -
I6L73_RS21050 (4390952) 4390952..4391263 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
I6L73_RS21055 (4391313) 4391313..4392041 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
I6L73_RS21060 (4392160) 4392160..4393593 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T206939 WP_004205323.1 NZ_CP077279:c4388555-4388145 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T206939 NZ_CP102772:1901246-1901530 [Bosea sp. NBC_00550]
TTGACGACCTATAGGCTCGCATTCCTGCCCTCGGCACGGAAGGAGTGGGACAAGCTTGGCGCGACCCTGCGCGAGCAGTT
CAAGAGGAAACTGGCCGAGCGGCTGATGAATCCTCGCGTGCAGGCCGATGCTCTTCACGGCCTGCCCGACCATTACAAGA
TCAAGCTACGCGCCGCCGGCTACCGGCTGGTCTACCGTGTCGAGGACGAAGAGGTTCCGATCGTCGTCGTCGTGATCGGC
AAGCGCGAACGGTCGCGGGTCTATGAAATCGCAAGGAAGCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT206939 WP_002916312.1 NZ_CP077279:c4388802-4388536 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206939 NZ_CP102772:1901014-1901259 [Bosea sp. NBC_00550]
ATGCAACGTGTCGAAGCGGAGATCGCGGTCAGCGTTTCCGATCTCAAGAAGAATCCGACCGCCGTCGTCGCCGGCGCGCG
GGGCAACCCCATCGCGATCCTGAACCACAATCGTGTCATGGCCTATATGGTACCCGCCGAGACCTATGAGGCGATGATGG
ACGCGCTTGACGATCAGGCACTCATAGAGGTCGCCAAGGCGCGGGCGAACGAGAAGAGCGAGCCCGTCAGCCTTGACGAC
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References