Detailed information of TA system TA206930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2646068..2647656
• Replicon: chromosome
• Accession: NZ_CP077279
• Organism: Klebsiella quasipneumoniae strain FDAARGOS 1443

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L73_RS12665
• Protein ID: WP_004205919.1
• Coordinates: 2646334..2647656 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2A5MFC9
• Locus tag: I6L73_RS12660
• Protein ID: WP_004205921.1
• Coordinates: 2646068..2646334 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L73_RS12635 (2641201)	2641201..2642124	+	924	WP_004205929.1	LysR family hpxDE operon transcriptional regulator HpxR	-
I6L73_RS12640 (2642105)	2642105..2643259	-	1155	WP_004205928.1	FAD-dependent urate hydroxylase HpxO	-
I6L73_RS12645 (2643605)	2643605..2644984	+	1380	WP_136085014.1	nucleobase:cation symporter-2 family protein	-
I6L73_RS12650 (2644962)	2644962..2645462	+	501	WP_080846687.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6L73_RS12655 (2645459)	2645459..2645785	+	327	WP_017900379.1	hydroxyisourate hydrolase	-
I6L73_RS12660 (2646068)	2646068..2646334	+	267	WP_004205921.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6L73_RS12665 (2646334)	2646334..2647656	+	1323	WP_004205919.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L73_RS12670 (2647673)	2647673..2648965	-	1293	WP_004205918.1	glycoside hydrolase family 10 protein	-
I6L73_RS12675 (2649107)	2649107..2649313	-	207	WP_004205917.1	helix-turn-helix transcriptional regulator	-
I6L73_RS12680 (2649316)	2649316..2649849	-	534	WP_004205916.1	hypothetical protein	-
I6L73_RS12685 (2649878)	2649878..2650222	-	345	WP_004205915.1	hypothetical protein	-
I6L73_RS12690 (2650209)	2650209..2651324	-	1116	WP_004205914.1	serine hydrolase domain-containing protein	-
I6L73_RS12695 (2651593)	2651593..2652375	-	783	WP_023289670.1	type I methionyl aminopeptidase	-
I6L73_RS12700 (2652356)	2652356..2652574	-	219	WP_002904808.1	ParD-like family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49013.27 Da
• Isoelectric Point: 8.2655

>T206930 WP_004205919.1 NZ_CP077279:2646334-2647656 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Nucleotide

• Length: 1323 bp

>T206930 NZ_CP102769:518539-518889 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9940.38 Da
• Isoelectric Point: 7.1997

>AT206930 WP_004205921.1 NZ_CP077279:2646068-2646334 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT206930 NZ_CP102769:518253-518534 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MFC9