Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1215288..1215907 Replicon chromosome
Accession NZ_CP077279
Organism Klebsiella quasipneumoniae strain FDAARGOS 1443

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6L73_RS05705 Protein ID WP_002892050.1
Coordinates 1215288..1215506 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6L73_RS05710 Protein ID WP_002892066.1
Coordinates 1215533..1215907 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L73_RS05670 (1211331) 1211331..1211594 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
I6L73_RS05675 (1211594) 1211594..1211734 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6L73_RS05680 (1211731) 1211731..1212429 - 699 WP_060656954.1 GNAT family protein -
I6L73_RS05685 (1212530) 1212530..1213987 + 1458 WP_032455644.1 PLP-dependent aminotransferase family protein -
I6L73_RS05690 (1213956) 1213956..1214426 - 471 WP_004204751.1 YlaC family protein -
I6L73_RS05695 (1214469) 1214469..1214591 + 123 WP_032426076.1 hypothetical protein -
I6L73_RS05700 (1214563) 1214563..1215129 - 567 WP_004204750.1 maltose O-acetyltransferase -
I6L73_RS05705 (1215288) 1215288..1215506 - 219 WP_002892050.1 HHA domain-containing protein Toxin
I6L73_RS05710 (1215533) 1215533..1215907 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6L73_RS05715 (1216392) 1216392..1219538 - 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
I6L73_RS05720 (1219561) 1219561..1220754 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T206929 WP_002892050.1 NZ_CP077279:c1215506-1215288 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T206929 NZ_CP102765:c2613-2293 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT206929 WP_002892066.1 NZ_CP077279:c1215907-1215533 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT206929 NZ_CP102765:c2300-2028 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References