Detailed information of TA system TA206928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 484667..485183
• Replicon: chromosome
• Accession: NZ_CP077279
• Organism: Klebsiella quasipneumoniae strain FDAARGOS 1443

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6L73_RS02295
• Protein ID: WP_004206511.1
• Coordinates: 484899..485183 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: I6L73_RS02290
• Protein ID: WP_002886901.1
• Coordinates: 484667..484909 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L73_RS02275 (480697)	480697..481437	+	741	WP_004206507.1	KDGP aldolase family protein	-
I6L73_RS02280 (481505)	481505..482656	+	1152	WP_004206508.1	lactonase family protein	-
I6L73_RS02285 (482679)	482679..484589	+	1911	WP_004206509.1	PRD domain-containing protein	-
I6L73_RS02290 (484667)	484667..484909	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6L73_RS02295 (484899)	484899..485183	+	285	WP_004206511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6L73_RS02300 (485187)	485187..485651	-	465	WP_004206512.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
I6L73_RS02305 (485962)	485962..488100	-	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
I6L73_RS02310 (488486)	488486..490141	-	1656	WP_004206514.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11163.01 Da
• Isoelectric Point: 10.4599

>T206928 WP_004206511.1 NZ_CP077279:484899-485183 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T206928 NZ_CP102764:17256-17549 [Acinetobacter baumannii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT206928 WP_002886901.1 NZ_CP077279:484667-484909 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT206928 NZ_CP102764:17021-17266 [Acinetobacter baumannii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACTGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0