Detailed information of TA system TA206927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1822732..1823503
• Replicon: chromosome
• Accession: NZ_CP077270
• Organism: Staphylococcus haemolyticus strain FDAARGOS 1453

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6L83_RS09050
• Protein ID: WP_011275410.1
• Coordinates: 1823354..1823503 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: I6L83_RS09045
• Protein ID: WP_011275409.1
• Coordinates: 1822732..1823331 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L83_RS09025 (I6L83_09025)	1818615..1820069	+	1455	WP_053019944.1	ABC transporter substrate-binding protein/permease	-
I6L83_RS09030 (I6L83_09030)	1820062..1820784	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
I6L83_RS09035 (I6L83_09035)	1820962..1822089	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6L83_RS09040 (I6L83_09040)	1822090..1822560	+	471	WP_016931343.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6L83_RS09045 (I6L83_09045)	1822732..1823331	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
I6L83_RS09050 (I6L83_09050)	1823354..1823503	+	150	WP_011275410.1	SAS053 family protein	Toxin
I6L83_RS09055 (I6L83_09055)	1823714..1824109	+	396	WP_057504773.1	hypothetical protein	-
I6L83_RS09060 (I6L83_09060)	1824316..1825701	+	1386	WP_011275412.1	class II fumarate hydratase	-
I6L83_RS09065 (I6L83_09065)	1825767..1826591	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
I6L83_RS09070 (I6L83_09070)	1826779..1827888	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T206927 WP_011275410.1 NZ_CP077270:1823354-1823503 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T206927 NZ_CP102763:c30911-30609 [Acinetobacter baumannii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT206927 WP_011275409.1 NZ_CP077270:1822732-1823331 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT206927 NZ_CP102763:c30608-30327 [Acinetobacter baumannii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2