206926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1676904..1677436 Replicon chromosome
Accession NZ_CP077270
Organism Staphylococcus haemolyticus strain FDAARGOS 1453

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag I6L83_RS08205 Protein ID WP_011275272.1
Coordinates 1677071..1677436 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag I6L83_RS08200 Protein ID WP_011275271.1
Coordinates 1676904..1677074 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L83_RS08175 (I6L83_08175) 1672690..1673169 + 480 WP_011275266.1 PH domain-containing protein -
I6L83_RS08180 (I6L83_08180) 1673162..1674685 + 1524 WP_016931363.1 PH domain-containing protein -
I6L83_RS08185 (I6L83_08185) 1674678..1675205 + 528 WP_016931364.1 PH domain-containing protein -
I6L83_RS08190 (I6L83_08190) 1675215..1675574 + 360 WP_037559766.1 holo-ACP synthase -
I6L83_RS08195 (I6L83_08195) 1675670..1676818 + 1149 WP_057504951.1 alanine racemase -
I6L83_RS08200 (I6L83_08200) 1676904..1677074 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6L83_RS08205 (I6L83_08205) 1677071..1677436 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6L83_RS08210 (I6L83_08210) 1677744..1678745 + 1002 WP_037559762.1 PP2C family protein-serine/threonine phosphatase -
I6L83_RS08215 (I6L83_08215) 1678844..1679170 + 327 WP_011275274.1 anti-sigma factor antagonist -
I6L83_RS08220 (I6L83_08220) 1679199..1679651 + 453 WP_046309853.1 anti-sigma B factor RsbW -
I6L83_RS08225 (I6L83_08225) 1679626..1680396 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T206926 WP_011275272.1 NZ_CP077270:1677071-1677436 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T206926 NZ_CP102763:c30608-30327 [Acinetobacter baumannii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT206926 WP_011275271.1 NZ_CP077270:1676904-1677074 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT206926 NZ_CP102763:c30911-30609 [Acinetobacter baumannii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References