Detailed information of TA system TA206925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1663979..1664490
• Replicon: chromosome
• Accession: NZ_CP077270
• Organism: Staphylococcus haemolyticus strain FDAARGOS 1453

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: I6L83_RS08140
• Protein ID: WP_011275259.1
• Coordinates: 1664284..1664490 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: I6L83_RS08135
• Protein ID: WP_011275258.1
• Coordinates: 1663979..1664272 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L83_RS08115 (I6L83_08115)	1659132..1660007	+	876	WP_011275255.1	membrane protein insertase YidC	-
I6L83_RS08120 (I6L83_08120)	1660202..1661518	+	1317	WP_058646542.1	ISL3-like element ISSha1 family transposase	-
I6L83_RS08125 (I6L83_08125)	1661567..1662208	-	642	WP_016931420.1	HD domain-containing protein	-
I6L83_RS08130 (I6L83_08130)	1662308..1663792	-	1485	WP_011275257.1	cardiolipin synthase	-
I6L83_RS08135 (I6L83_08135)	1663979..1664272	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
I6L83_RS08140 (I6L83_08140)	1664284..1664490	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
I6L83_RS08145 (I6L83_08145)	1664598..1664735	+	138	WP_103261999.1	Lmo0850 family protein	-
I6L83_RS08150 (I6L83_08150)	1665032..1666709	+	1678	Protein_1597	IS1182 family transposase	-
I6L83_RS08155 (I6L83_08155)	1666684..1667883	-	1200	WP_011275262.1	FtsW/RodA/SpoVE family cell cycle protein	-
I6L83_RS08160 (I6L83_08160)	1668301..1669371	+	1071	WP_057504952.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1660202..1666726	6524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T206925 WP_011275259.1 NZ_CP077270:1664284-1664490 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T206925 NZ_CP102763:c26750-26394 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT206925 WP_011275258.1 NZ_CP077270:1663979-1664272 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT206925 NZ_CP102763:c26401-26099 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8