Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 272225..272693 Replicon chromosome
Accession NZ_CP077270
Organism Staphylococcus haemolyticus strain FDAARGOS 1453

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag I6L83_RS01395 Protein ID WP_011276326.1
Coordinates 272505..272693 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag I6L83_RS01390 Protein ID WP_011276325.1
Coordinates 272225..272482 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L83_RS01355 (I6L83_01355) 267401..268126 - 726 WP_037558439.1 type I 3-dehydroquinate dehydratase -
I6L83_RS01360 (I6L83_01360) 268289..268711 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
I6L83_RS01365 (I6L83_01365) 268974..269465 + 492 WP_011276321.1 GNAT family N-acetyltransferase -
I6L83_RS01370 (I6L83_01370) 269597..270214 + 618 WP_011276322.1 LysE/ArgO family amino acid transporter -
I6L83_RS01375 (I6L83_01375) 270401..271009 - 609 WP_011276323.1 histidine phosphatase family protein -
I6L83_RS01380 (I6L83_01380) 271237..271479 + 243 WP_011276324.1 hypothetical protein -
I6L83_RS01385 (I6L83_01385) 271471..271674 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
I6L83_RS01390 (I6L83_01390) 272225..272482 + 258 WP_011276325.1 hypothetical protein Antitoxin
I6L83_RS01395 (I6L83_01395) 272505..272693 + 189 WP_011276326.1 hypothetical protein Toxin
I6L83_RS01400 (I6L83_01400) 272811..273392 + 582 WP_011276327.1 lipoprotein N-acylation protein LnsA -
I6L83_RS01405 (I6L83_01405) 273440..273676 - 237 WP_016931008.1 hypothetical protein -
I6L83_RS01410 (I6L83_01410) 273846..274592 + 747 WP_037558435.1 membrane lipoprotein lipid attachment site-containing protein -
I6L83_RS01415 (I6L83_01415) 274661..275269 - 609 WP_011276331.1 GNAT family N-acetyltransferase -
I6L83_RS01420 (I6L83_01420) 275406..276152 + 747 WP_011276332.1 poly-gamma-glutamate hydrolase family protein -
I6L83_RS01425 (I6L83_01425) 276228..276515 + 288 WP_011276333.1 hypothetical protein -
I6L83_RS01430 (I6L83_01430) 276761..276985 + 225 WP_011276334.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T206921 WP_011276326.1 NZ_CP077270:272505-272693 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T206921 NZ_CP102756:c4070888-4070475 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT206921 WP_011276325.1 NZ_CP077270:272225-272482 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT206921 NZ_CP102756:c4071135-4070869 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References