Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2620701..2621320 Replicon chromosome
Accession NZ_CP077265
Organism Klebsiella aerogenes strain FDAARGOS 1441

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag I6L71_RS12410 Protein ID WP_015367918.1
Coordinates 2621102..2621320 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag I6L71_RS12405 Protein ID WP_015367917.1
Coordinates 2620701..2621075 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L71_RS12395 (I6L71_12395) 2615860..2617059 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L71_RS12400 (I6L71_12400) 2617082..2620228 + 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit AcrB -
I6L71_RS12405 (I6L71_12405) 2620701..2621075 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
I6L71_RS12410 (I6L71_12410) 2621102..2621320 + 219 WP_015367918.1 HHA domain-containing protein Toxin
I6L71_RS12415 (I6L71_12415) 2621452..2622015 + 564 WP_045361854.1 maltose O-acetyltransferase -
I6L71_RS24740 2621990..2622094 - 105 Protein_2442 hypothetical protein -
I6L71_RS12420 (I6L71_12420) 2622141..2622605 + 465 WP_015367920.1 YlaC family protein -
I6L71_RS12425 (I6L71_12425) 2622580..2624034 - 1455 WP_020079453.1 PLP-dependent aminotransferase family protein -
I6L71_RS12430 (I6L71_12430) 2624137..2624847 + 711 WP_015704607.1 GNAT family protein -
I6L71_RS12435 (I6L71_12435) 2624844..2624984 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6L71_RS12440 (I6L71_12440) 2624987..2625247 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2620701..2630240 9539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T206919 WP_015367918.1 NZ_CP077265:2621102-2621320 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T206919 NZ_CP102756:c2871332-2871229 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT206919 WP_015367917.1 NZ_CP077265:2620701-2621075 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT206919 NZ_CP102756:2871227-2871370 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References