Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1378493..1379232 Replicon chromosome
Accession NZ_CP077265
Organism Klebsiella aerogenes strain FDAARGOS 1441

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag I6L71_RS06495 Protein ID WP_015705365.1
Coordinates 1378747..1379232 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag I6L71_RS06490 Protein ID WP_015705366.1
Coordinates 1378493..1378759 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L71_RS06470 (I6L71_06470) 1374785..1375402 + 618 WP_045360840.1 response regulator -
I6L71_RS06475 (I6L71_06475) 1375498..1375995 + 498 WP_045360838.1 heme-binding protein -
I6L71_RS06480 (I6L71_06480) 1376400..1376930 + 531 WP_045387819.1 N-acetyltransferase -
I6L71_RS06485 (I6L71_06485) 1376985..1378220 - 1236 WP_045387815.1 MFS transporter -
I6L71_RS06490 (I6L71_06490) 1378493..1378759 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
I6L71_RS06495 (I6L71_06495) 1378747..1379232 + 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
I6L71_RS06500 (I6L71_06500) 1379304..1380920 + 1617 WP_045387812.1 FAD-NAD(P)-binding protein -
I6L71_RS06505 (I6L71_06505) 1381039..1382139 + 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
I6L71_RS06510 (I6L71_06510) 1382196..1382354 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
I6L71_RS06515 (I6L71_06515) 1382615..1383685 + 1071 WP_020078888.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T206918 WP_015705365.1 NZ_CP077265:1378747-1379232 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T206918 NZ_CP102756:c2473647-2473363 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT206918 WP_015705366.1 NZ_CP077265:1378493-1378759 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT206918 NZ_CP102756:c2473885-2473637 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References