Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4201069..4201726 Replicon chromosome
Accession NZ_CP077264
Organism Enterobacter hormaechei strain FDAARGOS 1434

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag I6L64_RS20040 Protein ID WP_017382887.1
Coordinates 4201316..4201726 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag I6L64_RS20035 Protein ID WP_003863437.1
Coordinates 4201069..4201335 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L64_RS20015 (I6L64_20015) 4196475..4197908 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
I6L64_RS20020 (I6L64_20020) 4198025..4198756 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
I6L64_RS20025 (I6L64_20025) 4199023..4199682 + 660 WP_003863433.1 hemolysin III family protein -
I6L64_RS20030 (I6L64_20030) 4199794..4200774 - 981 WP_017692714.1 tRNA-modifying protein YgfZ -
I6L64_RS20035 (I6L64_20035) 4201069..4201335 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
I6L64_RS20040 (I6L64_20040) 4201316..4201726 + 411 WP_017382887.1 protein YgfX Toxin
I6L64_RS20045 (I6L64_20045) 4201728..4202249 - 522 WP_069596003.1 flavodoxin FldB -
I6L64_RS20050 (I6L64_20050) 4202351..4203247 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
I6L64_RS20055 (I6L64_20055) 4203276..4203989 + 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L64_RS20060 (I6L64_20060) 4203995..4205728 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T206907 WP_017382887.1 NZ_CP077264:4201316-4201726 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T206907 NZ_CP102749:4359730-4359981 [Pectobacterium parvum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGATCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCCCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCACCAGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT206907 WP_003863437.1 NZ_CP077264:4201069-4201335 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT206907 NZ_CP102749:4359978-4360232 [Pectobacterium parvum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATAGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTGGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References