Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3502035..3502639 Replicon chromosome
Accession NZ_CP077264
Organism Enterobacter hormaechei strain FDAARGOS 1434

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag I6L64_RS16615 Protein ID WP_071788668.1
Coordinates 3502035..3502220 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag I6L64_RS16620 Protein ID WP_023295606.1
Coordinates 3502235..3502639 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L64_RS16600 (I6L64_16600) 3497354..3499192 + 1839 WP_058686522.1 selenocysteine-specific translation elongation factor -
I6L64_RS16605 (I6L64_16605) 3499196..3500080 - 885 WP_003860164.1 ROK family protein -
I6L64_RS16610 (I6L64_16610) 3500247..3501785 + 1539 WP_033488028.1 aldehyde dehydrogenase AldB -
I6L64_RS16615 (I6L64_16615) 3502035..3502220 + 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
I6L64_RS16620 (I6L64_16620) 3502235..3502639 + 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6L64_RS16625 (I6L64_16625) 3502695..3504644 - 1950 WP_033488029.1 glycoside hydrolase family 127 protein -
I6L64_RS16630 (I6L64_16630) 3504655..3506055 - 1401 WP_033488030.1 MFS transporter -
I6L64_RS16635 (I6L64_16635) 3506281..3507099 + 819 WP_069596049.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T206906 WP_071788668.1 NZ_CP077264:3502035-3502220 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T206906 NZ_CP102749:4048768-4049076 [Pectobacterium parvum]
ATGCAATATAAAGTTTACCGTAATAACGGTAACAGCAACTCATACCCTTACCTGCTCAATGTCCAAAGTGACATCATTGG
GGAATTACATACCCGTCTGGTAATACCTTTGTTTCCATTAAACAAAGTTGCCAGACCACCAGCGCGAAGGCTAACGCCGA
TAGTCACTGTCGAAGGCAATGATTACCTGATAATGACCCATGAGATGGCGAGTGTACGCCGCTCACAACTTGGTCATGAA
GTGATGGATGCGCAGATGTACCGAAAAACAATCAAAGACGCCGTTGATTTCCTGCTGGATGGGTTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT206906 WP_023295606.1 NZ_CP077264:3502235-3502639 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT206906 NZ_CP102749:4048526-4048765 [Pectobacterium parvum]
ATGCCCGTAACAAGCATTCGCCATAAAAAAACGGTCAGTGTGACGCTGGAACCCATGCTGCTCCAACAAGCACGTGAAGC
CGGGATTAACCTATCCGCAATACTCACCGAGGCGTTGAAGAGAGAAATTCGCCTTTCTGAAGGGGAAAAATGGAAGCAGC
AGAACCAGAAGGCACTGCAGGAACTAAACCGTATCACAGATAAACACGGCTTATTATCCGACGATGACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References