Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2673030..2673606 Replicon chromosome
Accession NZ_CP077264
Organism Enterobacter hormaechei strain FDAARGOS 1434

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag I6L64_RS12700 Protein ID WP_015572580.1
Coordinates 2673319..2673606 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag I6L64_RS12695 Protein ID WP_017694570.1
Coordinates 2673030..2673332 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L64_RS12675 (I6L64_12675) 2669327..2669872 + 546 WP_033486712.1 YfaZ family outer membrane protein -
I6L64_RS12680 (I6L64_12680) 2670048..2671418 - 1371 WP_069595624.1 NAD-dependent succinate-semialdehyde dehydrogenase -
I6L64_RS12685 (I6L64_12685) 2671572..2672324 + 753 WP_033486709.1 AraC family transcriptional regulator -
I6L64_RS12690 (I6L64_12690) 2672363..2673001 + 639 WP_033486708.1 LysE family translocator -
I6L64_RS12695 (I6L64_12695) 2673030..2673332 - 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
I6L64_RS12700 (I6L64_12700) 2673319..2673606 - 288 WP_015572580.1 BrnT family toxin Toxin
I6L64_RS12705 (I6L64_12705) 2673776..2675047 + 1272 WP_033486707.1 DUF445 domain-containing protein -
I6L64_RS12710 (I6L64_12710) 2675044..2676120 - 1077 WP_015572578.1 DUF2955 domain-containing protein -
I6L64_RS12715 (I6L64_12715) 2676110..2677177 - 1068 WP_026080654.1 HlyD family secretion protein -
I6L64_RS12720 (I6L64_12720) 2677174..2677644 - 471 WP_033486706.1 MarR family transcriptional regulator -
I6L64_RS12725 (I6L64_12725) 2677794..2678512 - 719 Protein_2506 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T206904 WP_015572580.1 NZ_CP077264:c2673606-2673319 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

>T206904 NZ_CP102749:c3719417-3719103 [Pectobacterium parvum]
ATGCAAAAAATGCGCAGCATTCATAGCTTTCGGGATCAGTGGCTGGAAGATTTTTTTATGTATGGCAAGTCGCATAAAAA
GATACCTGCCGATGTGGTTACATCCTTGTCCCGCAAGCTGGATATCATCAACGCGGCGGTTTCAGCAAAAGACCTAAGAT
CGCCGCCGGGGAACCGATACGAGAACCTTAATCCGCCATTGGGGGAATATTCATCCATCAGAGTAAATATCCAATATCGC
CTGATTTTTAAATGGGTTGATGGTAAAGCAGAGGATATCTATCTTGACGACCATGGTTATAAAAAGCACAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT206904 WP_017694570.1 NZ_CP077264:c2673332-2673030 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT206904 NZ_CP102749:c3719024-3718683 [Pectobacterium parvum]
ATGGCACAGGCACAACGCAAGCCGACATCCGTAGGCGATGTCCTGTTATATGAATATCTAGAACCTACAGGTTTGAAGAT
TAATGACTTGGCGGAAATGCTGAATGTCCACCGTAACACAATCAGCGCACTGGTTAACAACAACCGTAAGTTAACGGTTG
ATATGGCATTCCGGTTGGCGAAAGCATTTGATACGTCAGTTGATTTCTGGCTGAACCTGCAAAATAGCGTTGACGTGTGG
GAAGTGGAAAACGACGCACGAACTCAGGAAGAAATTAGCCGGATCACTACGCTGGAAGATTTTCTGGCGCAACGTGATGA
AAATGTGAAAGACGTATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References