Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2185259..2185879 Replicon chromosome
Accession NZ_CP077264
Organism Enterobacter hormaechei strain FDAARGOS 1434

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag I6L64_RS10440 Protein ID WP_015571250.1
Coordinates 2185661..2185879 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag I6L64_RS10435 Protein ID WP_006809850.1
Coordinates 2185259..2185633 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L64_RS10425 (I6L64_10425) 2180386..2181579 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L64_RS10430 (I6L64_10430) 2181602..2184748 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
I6L64_RS10435 (I6L64_10435) 2185259..2185633 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
I6L64_RS10440 (I6L64_10440) 2185661..2185879 + 219 WP_015571250.1 HHA domain-containing protein Toxin
I6L64_RS10445 (I6L64_10445) 2186088..2186639 + 552 WP_017694396.1 maltose O-acetyltransferase -
I6L64_RS10450 (I6L64_10450) 2186756..2187223 + 468 WP_017383209.1 YlaC family protein -
I6L64_RS10455 (I6L64_10455) 2187195..2188655 - 1461 WP_017694397.1 PLP-dependent aminotransferase family protein -
I6L64_RS10460 (I6L64_10460) 2188757..2189467 + 711 WP_023303201.1 GNAT family protein -
I6L64_RS10465 (I6L64_10465) 2189464..2189604 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6L64_RS10470 (I6L64_10470) 2189607..2189867 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T206903 WP_015571250.1 NZ_CP077264:2185661-2185879 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T206903 NZ_CP102749:3399197-3399616 [Pectobacterium parvum]
ATGACAGATATTTTGCTCAACAAAAGCAGCACCATTCAAAGATGCCTACGTCGTATTCGTGAGGAATTCGATACTAAAGA
AGAGTTTCGCCAGAACTTCACCAAGCAAGATTCCGTCATACTTAACATACAACGCGCCTGCGAAGCCGCTATTGATATCG
CTAATTATCTTATCCGTATCAAGCATCTAGGCATACCACAAAGCAGCCGAGATAGCTTCGCGCTTCTTGCTGCAAACCAG
ATAATTACCATTGATCTGTCTGATAATTTGCAAAAAATGGTGGGATTAAGAAATATTGCCGTACATGACTATCAGGCGCT
CAATCTGGATATTGTCATCCACGTCATTTCTCATCGTTTAAGCGACTTTGAACGTTTCATCAAAGAAGTAGCCCGATACA
GCGACAGTCAGCACCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT206903 WP_006809850.1 NZ_CP077264:2185259-2185633 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT206903 NZ_CP102749:3398817-3399200 [Pectobacterium parvum]
ATGTTCGATAAGATCGTTTCAACATTAAAAAAACAGATACCCGACATCAAGATTATTTACCTCTTTGGTTCCCAGGCAAC
GGGCAATGCCAGAGCAGACAGCGATGTTGATATCGCCATCCTGGCGACGAGAGCATTGGATCCCGTCGAACGCTGGGAGC
TATCCAATCAATTAGCAAAGGAAGTGGGACGTGATGTCGATCTTATCGATTTATTGCAGGCCTCAACGGTATTAAAAATG
GAGATCGTTCGTAACGGCAAGCTACTTTATGATGCAAAAGCAGCGGCAGGAGAATTTGAAATGACAACACTTTCAATGTA
CCAGCATCTGCAAAGAGAGCGTGCGGATATCATTCGTAGCTTTAATCAGGATCTAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References