Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 989704..990443 Replicon chromosome
Accession NZ_CP077264
Organism Enterobacter hormaechei strain FDAARGOS 1434

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag I6L64_RS04740 Protein ID WP_003857133.1
Coordinates 989958..990443 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag I6L64_RS04735 Protein ID WP_003857131.1
Coordinates 989704..989970 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L64_RS04715 (I6L64_04715) 985186..986172 + 987 WP_017382341.1 DUF979 domain-containing protein -
I6L64_RS04720 (I6L64_04720) 986182..987177 + 996 WP_017382342.1 DUF2891 domain-containing protein -
I6L64_RS04725 (I6L64_04725) 987199..988581 - 1383 WP_047741273.1 MFS transporter -
I6L64_RS04730 (I6L64_04730) 988711..989640 + 930 WP_069595824.1 LysR family transcriptional regulator -
I6L64_RS04735 (I6L64_04735) 989704..989970 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
I6L64_RS04740 (I6L64_04740) 989958..990443 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
I6L64_RS04745 (I6L64_04745) 990494..991063 - 570 WP_033487774.1 hypothetical protein -
I6L64_RS04750 (I6L64_04750) 991079..992044 - 966 WP_033487773.1 hypothetical protein -
I6L64_RS04755 (I6L64_04755) 992329..992727 + 399 WP_063935741.1 hypothetical protein -
I6L64_RS04760 (I6L64_04760) 993044..993490 + 447 WP_032671143.1 DUF3290 domain-containing protein -
I6L64_RS04765 (I6L64_04765) 993500..994135 + 636 WP_015570517.1 DUF421 domain-containing protein -
I6L64_RS04770 (I6L64_04770) 994319..994864 - 546 WP_032671141.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T206900 WP_003857133.1 NZ_CP077264:989958-990443 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T206900 NZ_CP102749:c1078238-1077954 [Pectobacterium parvum]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCGCCCGTGCGGGAGCAGTTCAC
CAAAAAGTTGAAAGAGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCCGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGCTAGTGTACCAAGTGATCAAGCATGAGATCGTGGTGCTGGTTTTAGCTGTGGGTAAA
CGGGAACGCTCAGAAGTTTATAAAACAGCGAAAGACCGACTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT206900 WP_003857131.1 NZ_CP077264:989704-989970 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT206900 NZ_CP102749:c1078479-1078228 [Pectobacterium parvum]
ATGTCCGTACAACCTATCCTTGCGAATGCTGCCGTAAGTATCAGCGACTTTAAAAAATCGCCCAATGCCGCGCTGAAAGA
AGCTAACGGCGAGCCTGTAGCGGTGCTCACTAATGGCCGTATCTCTGGCTATTATGTTTCCCCTGAAACATGGGAAGCAC
TGGCCGATTATCAGGAAGATATCGAACTTGCCAAAATCGCCCGTTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References