Detailed information of TA system TA206892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 4892786..4893452
• Replicon: chromosome
• Accession: NZ_CP077262
• Organism: Citrobacter pasteurii strain FDAARGOS 1424

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A6N6K5Y9
• Locus tag: I6L54_RS23585
• Protein ID: WP_005132818.1
• Coordinates: 4893093..4893452 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: I6L54_RS23580
• Protein ID: WP_040229866.1
• Coordinates: 4892786..4893103 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L54_RS23535 (I6L54_23540)	4888003..4888815	+	813	WP_040229854.1	shikimate 5-dehydrogenase	-
I6L54_RS23540 (I6L54_23545)	4888849..4889166	-	318	WP_040229857.1	CcdB family protein	-
I6L54_RS23545 (I6L54_23550)	4889166..4889459	-	294	WP_040229861.1	type II toxin-antitoxin system CcdA family antitoxin	-
I6L54_RS23550 (I6L54_23555)	4889556..4889921	-	366	WP_005132806.1	hypothetical protein	-
I6L54_RS23555 (I6L54_23560)	4890063..4890224	+	162	WP_005132808.1	hypothetical protein	-
I6L54_RS23560 (I6L54_23565)	4890465..4891607	+	1143	WP_040229863.1	hypothetical protein	-
I6L54_RS23565 (I6L54_23570)	4891601..4891870	+	270	WP_040229864.1	hypothetical protein	-
I6L54_RS23570 (I6L54_23575)	4891954..4892082	-	129	Protein_4623	IS3 family transposase	-
I6L54_RS23575 (I6L54_23580)	4892498..4892776	+	279	WP_040229882.1	putative addiction module antidote protein	-
I6L54_RS23580 (I6L54_23585)	4892786..4893103	-	318	WP_040229866.1	helix-turn-helix transcriptional regulator	Antitoxin
I6L54_RS23585 (I6L54_23590)	4893093..4893452	-	360	WP_005132818.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6L54_RS23590 (I6L54_23595)	4893666..4894355	+	690	WP_040229868.1	dipeptidase PepE	-
I6L54_RS23595 (I6L54_23600)	4894502..4896133	-	1632	WP_040229869.1	Na/Pi cotransporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-87)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13476.49 Da
• Isoelectric Point: 10.3799

>T206892 WP_005132818.1 NZ_CP077262:c4893452-4893093 [Citrobacter pasteurii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEINLIYQRLKAAQRHAQESGYVT

Nucleotide

• Length: 360 bp

>T206892 NZ_CP102748:c1434239-1433979 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11503.40 Da
• Isoelectric Point: 6.9498

>AT206892 WP_040229866.1 NZ_CP077262:c4893103-4892786 [Citrobacter pasteurii]
MSHDIETSSGNVYADLGEYDAEQMQLKAQLAMVIGEILQCKGLTQQQAAQMLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Nucleotide

• Length: 318 bp

>AT206892 NZ_CP102748:c1434462-1434241 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Structures

Toxin

• AlphaFold DB: A0A6N6K5Y9