Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4000120..4000740 | Replicon | chromosome |
Accession | NZ_CP077262 | ||
Organism | Citrobacter pasteurii strain FDAARGOS 1424 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | I6L54_RS19435 | Protein ID | WP_002892050.1 |
Coordinates | 4000522..4000740 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | R8WZW8 |
Locus tag | I6L54_RS19430 | Protein ID | WP_003021733.1 |
Coordinates | 4000120..4000494 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6L54_RS19420 (I6L54_19425) | 3995267..3996460 | + | 1194 | WP_040232688.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
I6L54_RS19425 (I6L54_19430) | 3996483..3999632 | + | 3150 | WP_005125193.1 | efflux RND transporter permease AcrB | - |
I6L54_RS19430 (I6L54_19435) | 4000120..4000494 | + | 375 | WP_003021733.1 | Hha toxicity modulator TomB | Antitoxin |
I6L54_RS19435 (I6L54_19440) | 4000522..4000740 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
I6L54_RS19440 (I6L54_19445) | 4000929..4001480 | + | 552 | WP_005125192.1 | maltose O-acetyltransferase | - |
I6L54_RS19445 (I6L54_19450) | 4001597..4002067 | + | 471 | WP_040232692.1 | YlaC family protein | - |
I6L54_RS19450 (I6L54_19455) | 4002145..4002285 | - | 141 | WP_005125190.1 | type B 50S ribosomal protein L36 | - |
I6L54_RS19455 (I6L54_19460) | 4002287..4002547 | - | 261 | WP_005125189.1 | type B 50S ribosomal protein L31 | - |
I6L54_RS19460 (I6L54_19465) | 4002736..4004289 | + | 1554 | WP_040232693.1 | EAL domain-containing protein | - |
I6L54_RS19465 (I6L54_19470) | 4004344..4004697 | - | 354 | WP_005125187.1 | DUF1428 family protein | - |
I6L54_RS19470 (I6L54_19475) | 4004762..4005391 | - | 630 | WP_005125186.1 | membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T206890 WP_002892050.1 NZ_CP077262:4000522-4000740 [Citrobacter pasteurii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T206890 NZ_CP102748:680916-681185 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14427.23 Da Isoelectric Point: 5.5653
>AT206890 WP_003021733.1 NZ_CP077262:4000120-4000494 [Citrobacter pasteurii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT206890 NZ_CP102748:680699-680926 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R8WZW8 |