Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4000120..4000740 Replicon chromosome
Accession NZ_CP077262
Organism Citrobacter pasteurii strain FDAARGOS 1424

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6L54_RS19435 Protein ID WP_002892050.1
Coordinates 4000522..4000740 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag I6L54_RS19430 Protein ID WP_003021733.1
Coordinates 4000120..4000494 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L54_RS19420 (I6L54_19425) 3995267..3996460 + 1194 WP_040232688.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L54_RS19425 (I6L54_19430) 3996483..3999632 + 3150 WP_005125193.1 efflux RND transporter permease AcrB -
I6L54_RS19430 (I6L54_19435) 4000120..4000494 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
I6L54_RS19435 (I6L54_19440) 4000522..4000740 + 219 WP_002892050.1 HHA domain-containing protein Toxin
I6L54_RS19440 (I6L54_19445) 4000929..4001480 + 552 WP_005125192.1 maltose O-acetyltransferase -
I6L54_RS19445 (I6L54_19450) 4001597..4002067 + 471 WP_040232692.1 YlaC family protein -
I6L54_RS19450 (I6L54_19455) 4002145..4002285 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
I6L54_RS19455 (I6L54_19460) 4002287..4002547 - 261 WP_005125189.1 type B 50S ribosomal protein L31 -
I6L54_RS19460 (I6L54_19465) 4002736..4004289 + 1554 WP_040232693.1 EAL domain-containing protein -
I6L54_RS19465 (I6L54_19470) 4004344..4004697 - 354 WP_005125187.1 DUF1428 family protein -
I6L54_RS19470 (I6L54_19475) 4004762..4005391 - 630 WP_005125186.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T206890 WP_002892050.1 NZ_CP077262:4000522-4000740 [Citrobacter pasteurii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T206890 NZ_CP102748:680916-681185 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT206890 WP_003021733.1 NZ_CP077262:4000120-4000494 [Citrobacter pasteurii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT206890 NZ_CP102748:680699-680926 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References