Detailed information of TA system TA206889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2704876..2705515
• Replicon: chromosome
• Accession: NZ_CP077262
• Organism: Citrobacter pasteurii strain FDAARGOS 1424

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A6N6JZ10
• Locus tag: I6L54_RS13240
• Protein ID: WP_005126745.1
• Coordinates: 2704876..2705052 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I6L54_RS13245
• Protein ID: WP_137378530.1
• Coordinates: 2705099..2705515 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L54_RS13220 (I6L54_13225)	2701654..2701884	-	231	WP_005126741.1	DUF2554 family protein	-
I6L54_RS13225 (I6L54_13230)	2702074..2702199	-	126	WP_005126742.1	DUF2474 domain-containing protein	-
I6L54_RS13230 (I6L54_13235)	2702199..2703209	-	1011	WP_040230985.1	cytochrome d ubiquinol oxidase subunit II	-
I6L54_RS13235 (I6L54_13240)	2703209..2704612	-	1404	WP_040230988.1	cytochrome ubiquinol oxidase subunit I	-
I6L54_RS13240 (I6L54_13245)	2704876..2705052	+	177	WP_005126745.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6L54_RS13245 (I6L54_13250)	2705099..2705515	+	417	WP_137378530.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6L54_RS13250 (I6L54_13255)	2705608..2707017	+	1410	WP_005126747.1	PLP-dependent aminotransferase family protein	-
I6L54_RS13255 (I6L54_13260)	2707347..2708492	+	1146	WP_040230992.1	ABC transporter substrate-binding protein	-
I6L54_RS13260 (I6L54_13265)	2708509..2709525	+	1017	WP_040230994.1	ABC transporter ATP-binding protein	-
I6L54_RS13265 (I6L54_13270)	2709526..2710470	+	945	WP_005126750.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (82-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6754.83 Da
• Isoelectric Point: 11.2510

>T206889 WP_005126745.1 NZ_CP077262:2704876-2705052 [Citrobacter pasteurii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLL

Nucleotide

• Length: 177 bp

>T206889 NZ_CP102747:c1455491-1455309 [Streptococcus parasuis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCCATAACCATTCCCCACGGTGAAATAAACAAATATACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15068.28 Da
• Isoelectric Point: 4.5716

>AT206889 WP_137378530.1 NZ_CP077262:2705099-2705515 [Citrobacter pasteurii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVGAEDDYVEIPLSAASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Nucleotide

• Length: 417 bp

>AT206889 NZ_CP102747:c1455271-1454822 [Streptococcus parasuis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCGCCCTACTTTGTAACATTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGACGAGACATTCCTACCCCGTCTTCTATAAATACTTTGTCATTAGTAGATAATAACCCTTTC
CATGATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGATGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAGATCCATGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6N6JZ10