Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1221001..1221655 Replicon chromosome
Accession NZ_CP077262
Organism Citrobacter pasteurii strain FDAARGOS 1424

Toxin (Protein)


Gene name cptA Uniprot ID A0A6N6JXZ4
Locus tag I6L54_RS05980 Protein ID WP_005123352.1
Coordinates 1221248..1221655 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6N6K0R3
Locus tag I6L54_RS05975 Protein ID WP_005123351.1
Coordinates 1221001..1221267 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L54_RS05950 (I6L54_05950) 1216204..1217637 - 1434 WP_040232131.1 6-phospho-beta-glucosidase BglA -
I6L54_RS05955 (I6L54_05955) 1217758..1218486 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
I6L54_RS05960 (I6L54_05960) 1218539..1218850 + 312 WP_040232132.1 N(4)-acetylcytidine aminohydrolase -
I6L54_RS05965 (I6L54_05965) 1219014..1219673 + 660 WP_003838267.1 hemolysin III family protein -
I6L54_RS05970 (I6L54_05970) 1219765..1220745 - 981 WP_005123350.1 tRNA-modifying protein YgfZ -
I6L54_RS05975 (I6L54_05975) 1221001..1221267 + 267 WP_005123351.1 FAD assembly factor SdhE Antitoxin
I6L54_RS05980 (I6L54_05980) 1221248..1221655 + 408 WP_005123352.1 protein YgfX Toxin
I6L54_RS05985 (I6L54_05985) 1221747..1222268 - 522 WP_040232135.1 flavodoxin FldB -
I6L54_RS05990 (I6L54_05990) 1222382..1223278 + 897 WP_005123354.1 site-specific tyrosine recombinase XerD -
I6L54_RS05995 (I6L54_05995) 1223302..1224015 + 714 WP_040232137.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L54_RS06000 (I6L54_06000) 1224021..1225754 + 1734 WP_005123356.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15928.81 Da        Isoelectric Point: 10.9468

>T206880 WP_005123352.1 NZ_CP077262:1221248-1221655 [Citrobacter pasteurii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGDIRLLMDGRLRWQGQ
EWSIVCTPWMIKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

>T206880 NZ_CP077262:1221248-1221655 [Citrobacter pasteurii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCACAGTGGCTCTCTCTGCTCATTCATGGGCTGGTTGCGGT
ATTCATTTTATTGATGCCCTGGCCATTGAGCTACACTCCATTATGGTTGGTTCTGCTCTCTCTGGTGGTGTTTGATAGCG
TACGCAGTCAGCGTCGCATTAACGCTTGTCAGGGAGATATTAGACTGTTAATGGACGGTCGCCTGCGCTGGCAGGGGCAG
GAGTGGTCTATCGTTTGTACACCCTGGATGATTAAAACGGGCATGATGCTGCGTTTGCGTTCCGATGCGGGAAAACGTCA
GCATTTGTGGCTGGCAGCGGACAGCATGGATGACGCAGAGTGGCGGGATTTGCGGCGGTTAATGCTGCAACAGGCGAAGC
AGGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10642.16 Da        Isoelectric Point: 5.1700

>AT206880 WP_005123351.1 NZ_CP077262:1221001-1221267 [Citrobacter pasteurii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206880 NZ_CP077262:1221001-1221267 [Citrobacter pasteurii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGACGAAGAAAAACGCATCTTTATCCGTCTGCTGGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGAGCAGCTGGAGCAGATGGTGCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JXZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A6N6K0R3

References