Detailed information of TA system TA206879

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1051882..1052667
• Replicon: chromosome
• Accession: NZ_CP077262
• Organism: Citrobacter pasteurii strain FDAARGOS 1424

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6L54_RS05135
• Protein ID: WP_040063377.1
• Coordinates: 1051882..1052259 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6L54_RS05140
• Protein ID: WP_038633768.1
• Coordinates: 1052308..1052667 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L54_RS05110 (I6L54_05110)	1049141..1049602	+	462	WP_040229929.1	hypothetical protein	-
I6L54_RS05115 (I6L54_05115)	1049605..1049826	+	222	WP_040229952.1	helix-turn-helix transcriptional regulator	-
I6L54_RS05120 (I6L54_05120)	1050241..1051089	-	849	WP_040229927.1	DUF4942 domain-containing protein	-
I6L54_RS05125 (I6L54_05125)	1051170..1051364	-	195	WP_038633777.1	DUF957 domain-containing protein	-
I6L54_RS05130 (I6L54_05130)	1051394..1051885	-	492	WP_040063379.1	DUF5983 family protein	-
I6L54_RS05135 (I6L54_05135)	1051882..1052259	-	378	WP_040063377.1	TA system toxin CbtA family protein	Toxin
I6L54_RS05140 (I6L54_05140)	1052308..1052667	-	360	WP_038633768.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6L54_RS05145 (I6L54_05145)	1052690..1052911	-	222	WP_038633763.1	DUF987 domain-containing protein	-
I6L54_RS05150 (I6L54_05150)	1052923..1053408	-	486	WP_040229951.1	DNA repair protein RadC	-
I6L54_RS05155 (I6L54_05155)	1053461..1053856	-	396	WP_044268460.1	antirestriction protein	-
I6L54_RS05160 (I6L54_05160)	1053934..1054197	-	264	WP_001149870.1	hypothetical protein	-
I6L54_RS05165 (I6L54_05165)	1054197..1055015	-	819	WP_040229920.1	DUF932 domain-containing protein	-
I6L54_RS05170 (I6L54_05170)	1055131..1055381	-	251	Protein_990	DUF905 family protein	-
I6L54_RS05175 (I6L54_05175)	1055572..1056039	-	468	WP_000727137.1	hypothetical protein	-
I6L54_RS05180 (I6L54_05180)	1056136..1056537	-	402	WP_000819262.1	hypothetical protein	-
I6L54_RS05185 (I6L54_05185)	1056743..1057630	-	888	WP_040229917.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1014080..1061259	47179

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14020.87 Da
• Isoelectric Point: 6.8604

>T206879 WP_040063377.1 NZ_CP077262:c1052259-1051882 [Citrobacter pasteurii]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRAVTDITTGKYSKMTR

Nucleotide

• Length: 378 bp

>T206879 NZ_CP102746:597312-597581 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13318.30 Da
• Isoelectric Point: 7.4424

>AT206879 WP_038633768.1 NZ_CP077262:c1052667-1052308 [Citrobacter pasteurii]
MLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQAFPVLLKQMELMLVSGELS
PRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS

Nucleotide

• Length: 360 bp

>AT206879 NZ_CP102746:597095-597322 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA