Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 122215..122831 | Replicon | chromosome |
Accession | NZ_CP077262 | ||
Organism | Citrobacter pasteurii strain FDAARGOS 1424 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A6N6JZM7 |
Locus tag | I6L54_RS00630 | Protein ID | WP_005121821.1 |
Coordinates | 122215..122589 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A923DW40 |
Locus tag | I6L54_RS00635 | Protein ID | WP_005121822.1 |
Coordinates | 122589..122831 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6L54_RS00615 (I6L54_00615) | 119718..120620 | + | 903 | WP_005121817.1 | formate dehydrogenase O subunit beta | - |
I6L54_RS00620 (I6L54_00620) | 120617..121252 | + | 636 | WP_040233076.1 | formate dehydrogenase cytochrome b556 subunit | - |
I6L54_RS00625 (I6L54_00625) | 121249..122178 | + | 930 | WP_005121819.1 | formate dehydrogenase accessory protein FdhE | - |
I6L54_RS00630 (I6L54_00630) | 122215..122589 | - | 375 | WP_005121821.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
I6L54_RS00635 (I6L54_00635) | 122589..122831 | - | 243 | WP_005121822.1 | CopG family transcriptional regulator | Antitoxin |
I6L54_RS00640 (I6L54_00640) | 123037..123966 | + | 930 | WP_005121823.1 | alpha/beta hydrolase | - |
I6L54_RS00645 (I6L54_00645) | 124052..124363 | + | 312 | WP_040233077.1 | type II toxin-antitoxin system HigB family toxin | - |
I6L54_RS00650 (I6L54_00650) | 124360..124806 | + | 447 | WP_040233078.1 | helix-turn-helix domain-containing protein | - |
I6L54_RS00655 (I6L54_00655) | 124818..125759 | - | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
I6L54_RS00660 (I6L54_00660) | 125804..126241 | - | 438 | WP_003028671.1 | D-aminoacyl-tRNA deacylase | - |
I6L54_RS00665 (I6L54_00665) | 126238..127110 | - | 873 | WP_040233081.1 | virulence factor BrkB family protein | - |
I6L54_RS00670 (I6L54_00670) | 127104..127703 | - | 600 | WP_040233083.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13655.81 Da Isoelectric Point: 8.0276
>T206876 WP_005121821.1 NZ_CP077262:c122589-122215 [Citrobacter pasteurii]
MVKGSALFDTNILIDLFSGRSEAKQAIETWPPQNAISLITWMEVMVGAKKYHQESCTRVALSAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
MVKGSALFDTNILIDLFSGRSEAKQAIETWPPQNAISLITWMEVMVGAKKYHQESCTRVALSAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
Download Length: 375 bp
>T206876 NZ_CP102740:31564-31716 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9396.71 Da Isoelectric Point: 4.3543
>AT206876 WP_005121822.1 NZ_CP077262:c122831-122589 [Citrobacter pasteurii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQEQAETTISSALGLWKGCEEDGVEYQRKLREEW
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQEQAETTISSALGLWKGCEEDGVEYQRKLREEW
Download Length: 243 bp
>AT206876 NZ_CP102740:c31509-31452 [Salmonella enterica subsp. enterica serovar Kentucky]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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