Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4449050..4449758 Replicon chromosome
Accession NZ_CP077260
Organism Providencia rettgeri strain FDAARGOS 1449

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6L79_RS20585 Protein ID WP_036958833.1
Coordinates 4449369..4449758 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6L79_RS20580 Protein ID WP_004905885.1
Coordinates 4449050..4449379 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L79_RS20565 (I6L79_20565) 4444995..4445966 - 972 WP_004905881.1 efflux RND transporter periplasmic adaptor subunit -
I6L79_RS20570 (I6L79_20570) 4446624..4448309 + 1686 WP_004905883.1 sensor histidine kinase -
I6L79_RS20575 (I6L79_20575) 4448329..4449045 + 717 WP_004905884.1 two-component system response regulator BtsR -
I6L79_RS20580 (I6L79_20580) 4449050..4449379 - 330 WP_004905885.1 helix-turn-helix domain-containing protein Antitoxin
I6L79_RS20585 (I6L79_20585) 4449369..4449758 - 390 WP_036958833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L79_RS20590 (I6L79_20590) 4449912..4451843 - 1932 WP_004905887.1 DEAD/DEAH family ATP-dependent RNA helicase -
I6L79_RS20595 (I6L79_20595) 4452014..4452931 - 918 WP_226617020.1 lipoprotein NlpI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-93)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14486.75 Da        Isoelectric Point: 8.8281

>T206875 WP_036958833.1 NZ_CP077260:c4449758-4449369 [Providencia rettgeri]
VAFYKISSFKRSTKKIKIMDKHLLKAANEVLAGVYEADLGSGVIKKRIAINGKGKSGGGRVIIFFKVSHHLFFADGWEKC
NIAAKGVKEIEDDELDAYKNLSRLFLNYTDDKIADLVLHNILEELTDEQ

Download         Length: 390 bp

>T206875 NZ_CP102739:c4686465-4685980 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGGACATGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCAACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGAAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12235.50 Da        Isoelectric Point: 10.3803

>AT206875 WP_004905885.1 NZ_CP077260:c4449379-4449050 [Providencia rettgeri]
MSNKLENMLELAKELHQVDAAPKSLVTDLEQKVGNRKINNKIKVVPMMSGAQIKQLRAQYGMSQAMLALALGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Download         Length: 330 bp

>AT206875 NZ_CP102739:c4686740-4686453 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References