Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4441968..4442553 Replicon chromosome
Accession NZ_CP077260
Organism Providencia rettgeri strain FDAARGOS 1449

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag I6L79_RS20545 Protein ID WP_004905874.1
Coordinates 4441968..4442285 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag I6L79_RS20550 Protein ID WP_004905876.1
Coordinates 4442266..4442553 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L79_RS20515 (I6L79_20515) 4437671..4437922 - 252 WP_004905862.1 DUF1471 domain-containing protein -
I6L79_RS20520 (I6L79_20520) 4438193..4438531 + 339 WP_004905864.1 GIY-YIG nuclease family protein -
I6L79_RS20525 (I6L79_20525) 4438504..4439007 - 504 WP_004905865.1 N-acetyltransferase -
I6L79_RS20530 (I6L79_20530) 4439001..4439525 - 525 WP_004905868.1 SCP2 domain-containing protein -
I6L79_RS20535 (I6L79_20535) 4440040..4441035 + 996 WP_004905870.1 peptidase U32 family protein -
I6L79_RS20540 (I6L79_20540) 4441053..4441928 + 876 WP_004905872.1 U32 family peptidase -
I6L79_RS20545 (I6L79_20545) 4441968..4442285 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6L79_RS20550 (I6L79_20550) 4442266..4442553 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6L79_RS20555 (I6L79_20555) 4442684..4443838 - 1155 WP_004905877.1 ABC transporter permease -
I6L79_RS20560 (I6L79_20560) 4443838..4444983 - 1146 WP_004905879.1 ABC transporter permease -
I6L79_RS20565 (I6L79_20565) 4444995..4445966 - 972 WP_004905881.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T206874 WP_004905874.1 NZ_CP077260:c4442285-4441968 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T206874 NZ_CP102739:c4582435-4581917 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGACAACCTGACAATAGAGATTCTGGCTGATAACGCAGAATACAACTGGCGGCAGTTCGACTGCGGTGAGGCATCATT
AAACCTTTTTTTAACGCAGCATCTTCAGCGCCAGCATAACAACAAAATCTTGCGCGGTTATGTACTCAGAACCACTACGC
CAGAACGGCGAGTGTTGGGGTATTACACCCTGTCAGGAAGCTGCTTTGAACGCGCGTCGTTGCCTTCCAGAACCCAGCAA
AAGCGCATCCCTTACCAGAATATCCCCAGCGTTACGCTGGGCCGTTTAGCGGTCGATCTCTCATTACAGGGAAAAGGGTG
GGGAGCTATATTGGTCACGCATGCGATGAAAGTGGTGTGGTCGGCATCACTGGCCGTTGGGATTCATGGCATCTTTGTGG
AAGCGTTAAACGAAAAAGCCCAGGCCTTTTATCAGCGGCTGGGCTTTATTTCTTTATCCGGAGAAAACGAGCACGCGCTG
TTTTACCCGACAAAGTCGATTGAGCAACTTTTTGGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT206874 WP_004905876.1 NZ_CP077260:c4442553-4442266 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT206874 NZ_CP102739:c4582708-4582439 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCCTAAAAAAACAGCGTATCGATCTGCGGCTCACAGACGGCGATAAAAGCATGATTGAAGAAGCGGCCGCCAT
TACTAATCAATCAATCACGCAATTTATGTTGAATAGCGCAGCGGAGCGAGCCGCAGAAGTGCTTGAACAGCACCGTCGGG
TTATTCTTAATGAAGCATCCTGGGCGCGAGTCATGGATGCGCTTAGTCATCCTCCCACCCCCAATGAGAAATTAAAACGC
GCGGCGCAACGTCTACAAGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References