Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3172168..3172703 Replicon chromosome
Accession NZ_CP077260
Organism Providencia rettgeri strain FDAARGOS 1449

Toxin (Protein)


Gene name ccdB Uniprot ID D4BV22
Locus tag I6L79_RS14695 Protein ID WP_004255694.1
Coordinates 3172395..3172703 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D4BV21
Locus tag I6L79_RS14690 Protein ID WP_004255691.1
Coordinates 3172168..3172395 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L79_RS14665 (I6L79_14665) 3167351..3167653 + 303 WP_004255680.1 flagellar biosynthesis anti-sigma factor FlgM -
I6L79_RS14670 (I6L79_14670) 3167663..3168103 + 441 WP_004255682.1 flagellar export chaperone FlgN -
I6L79_RS14675 (I6L79_14675) 3168150..3168428 - 279 WP_004255684.1 helix-turn-helix domain-containing protein -
I6L79_RS14680 (I6L79_14680) 3168661..3170760 - 2100 WP_004255687.1 flagellar biosynthesis protein FlhA -
I6L79_RS14685 (I6L79_14685) 3170753..3171904 - 1152 WP_004255688.1 flagellar biosynthesis protein FlhB -
I6L79_RS14690 (I6L79_14690) 3172168..3172395 + 228 WP_004255691.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6L79_RS14695 (I6L79_14695) 3172395..3172703 + 309 WP_004255694.1 CcdB family protein Toxin
I6L79_RS14700 (I6L79_14700) 3172719..3173276 + 558 WP_004255696.1 hypothetical protein -
I6L79_RS14705 (I6L79_14705) 3173319..3173525 - 207 WP_272661075.1 helix-turn-helix transcriptional regulator -
I6L79_RS14710 (I6L79_14710) 3173723..3174361 - 639 WP_004255702.1 protein phosphatase CheZ -
I6L79_RS14715 (I6L79_14715) 3174386..3174778 - 393 WP_004255705.1 chemotaxis response regulator CheY -
I6L79_RS14720 (I6L79_14720) 3174820..3175887 - 1068 WP_217005628.1 chemotaxis response regulator protein-glutamate methylesterase -
I6L79_RS14725 (I6L79_14725) 3175887..3176723 - 837 WP_004255713.1 chemotaxis protein-glutamate O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11763.84 Da        Isoelectric Point: 7.2408

>T206873 WP_004255694.1 NZ_CP077260:3172395-3172703 [Providencia rettgeri]
MQYCLYQNREDTVKYPYLLDIQSNIIDILNTRLVIPLFDSRLVKKPLPVRLNPQLSINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Download         Length: 309 bp

>T206873 NZ_CP102739:c4047986-4047573 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8688.92 Da        Isoelectric Point: 8.9375

>AT206873 WP_004255691.1 NZ_CP077260:3172168-3172395 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Download         Length: 228 bp

>AT206873 NZ_CP102739:c4048233-4047967 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4BV22

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q922

References