Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2611219..2612135 Replicon chromosome
Accession NZ_CP077260
Organism Providencia rettgeri strain FDAARGOS 1449

Toxin (Protein)


Gene name - Uniprot ID D4BTW9
Locus tag I6L79_RS11900 Protein ID WP_004254505.1
Coordinates 2611677..2612135 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID D4BTW8
Locus tag I6L79_RS11895 Protein ID WP_004254502.1
Coordinates 2611219..2611680 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L79_RS11865 (I6L79_11865) 2606885..2607499 + 615 WP_004254484.1 LysE family translocator -
I6L79_RS11870 (I6L79_11870) 2607523..2607996 - 474 WP_036957747.1 NUDIX domain-containing protein -
I6L79_RS11875 (I6L79_11875) 2608348..2608989 - 642 WP_004254492.1 leucine efflux protein LeuE -
I6L79_RS11880 (I6L79_11880) 2609571..2610164 + 594 WP_282550938.1 AzlC family ABC transporter permease -
I6L79_RS11885 (I6L79_11885) 2610161..2610475 + 315 WP_004254498.1 AzlD domain-containing protein -
I6L79_RS11890 (I6L79_11890) 2610663..2611130 + 468 WP_036957750.1 DUF1456 family protein -
I6L79_RS11895 (I6L79_11895) 2611219..2611680 + 462 WP_004254502.1 DUF2384 domain-containing protein Antitoxin
I6L79_RS11900 (I6L79_11900) 2611677..2612135 + 459 WP_004254505.1 RES domain-containing protein Toxin
I6L79_RS11905 (I6L79_11905) 2612136..2613026 - 891 WP_004254508.1 LysR family transcriptional regulator -
I6L79_RS11910 (I6L79_11910) 2613072..2614031 - 960 WP_004254511.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
I6L79_RS11915 (I6L79_11915) 2614137..2614559 - 423 WP_004254515.1 helix-turn-helix domain-containing protein -
I6L79_RS11920 (I6L79_11920) 2614590..2615117 - 528 WP_036957752.1 GNAT family N-acetyltransferase -
I6L79_RS11925 (I6L79_11925) 2615134..2616600 - 1467 WP_036957754.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-145)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17088.65 Da        Isoelectric Point: 6.2048

>T206872 WP_004254505.1 NZ_CP077260:2611677-2612135 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDILLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Download         Length: 459 bp

>T206872 NZ_CP102739:3879543-3880070 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCATGGATTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGACACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17090.56 Da        Isoelectric Point: 9.9140

>AT206872 WP_004254502.1 NZ_CP077260:2611219-2611680 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT206872 NZ_CP102739:3879256-3879546 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4BTW9

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q7V6

References