Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 921565..922211 Replicon chromosome
Accession NZ_CP077260
Organism Providencia rettgeri strain FDAARGOS 1449

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag I6L79_RS04035 Protein ID WP_004905417.1
Coordinates 921565..921768 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag I6L79_RS04040 Protein ID WP_004905413.1
Coordinates 921843..922211 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L79_RS04010 (I6L79_04010) 917632..917970 + 339 WP_004905421.1 P-II family nitrogen regulator -
I6L79_RS04015 (I6L79_04015) 918020..919267 + 1248 WP_164456268.1 ammonium transporter AmtB -
I6L79_RS04020 (I6L79_04020) 919406..920275 - 870 WP_036958583.1 acyl-CoA thioesterase II -
I6L79_RS04025 (I6L79_04025) 920514..920972 + 459 WP_004905418.1 YbaY family lipoprotein -
I6L79_RS04035 (I6L79_04035) 921565..921768 - 204 WP_004905417.1 HHA domain-containing protein Toxin
I6L79_RS04040 (I6L79_04040) 921843..922211 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
I6L79_RS04045 (I6L79_04045) 922735..924105 - 1371 WP_004905412.1 murein transglycosylase D -
I6L79_RS04050 (I6L79_04050) 924187..924942 - 756 WP_004905408.1 hydroxyacylglutathione hydrolase -
I6L79_RS04055 (I6L79_04055) 924983..925717 + 735 WP_004905406.1 methyltransferase domain-containing protein -
I6L79_RS04060 (I6L79_04060) 925714..926184 - 471 WP_004905405.1 ribonuclease HI -
I6L79_RS04065 (I6L79_04065) 926239..926982 + 744 WP_004905404.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T206870 WP_004905417.1 NZ_CP077260:c921768-921565 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T206870 NZ_CP102739:c2476156-2475872 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT206870 WP_004905413.1 NZ_CP077260:c922211-921843 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT206870 NZ_CP102739:c2476394-2476146 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References