Detailed information of TA system TA206869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 63341..64917
• Replicon: chromosome
• Accession: NZ_CP077260
• Organism: Providencia rettgeri strain FDAARGOS 1449

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: D4C5Q8
• Locus tag: I6L79_RS00305
• Protein ID: WP_004906221.1
• Coordinates: 63341..64660 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6L79_RS00310
• Protein ID: WP_036959176.1
• Coordinates: 64660..64917 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L79_RS00295 (I6L79_00295)	59278..62325	-	3048	WP_282550878.1	formate dehydrogenase-N subunit alpha	-
I6L79_RS00300 (I6L79_00300)	62500..63330	+	831	WP_036959175.1	formate dehydrogenase accessory sulfurtransferase FdhD	-
I6L79_RS00305 (I6L79_00305)	63341..64660	-	1320	WP_004906221.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L79_RS00310 (I6L79_00310)	64660..64917	-	258	WP_036959176.1	helix-turn-helix domain-containing protein	Antitoxin
I6L79_RS00315 (I6L79_00315)	65247..66611	-	1365	WP_004906223.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
I6L79_RS00320 (I6L79_00320)	66713..68362	-	1650	WP_004906225.1	membrane protein insertase YidC	-
I6L79_RS00325 (I6L79_00325)	68365..68625	-	261	WP_036959180.1	membrane protein insertion efficiency factor YidD	-
I6L79_RS00330 (I6L79_00330)	68589..68948	-	360	WP_004906229.1	ribonuclease P protein component	-
I6L79_RS00335 (I6L79_00335)	68970..69113	-	144	WP_004906236.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49978.00 Da
• Isoelectric Point: 6.6933

>T206869 WP_004906221.1 NZ_CP077260:c64660-63341 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPRSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTKGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVLKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Nucleotide

• Length: 1320 bp

>T206869 NZ_CP102739:c1482701-1482483 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9628.85 Da
• Isoelectric Point: 9.6898

>AT206869 WP_036959176.1 NZ_CP077260:c64917-64660 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Nucleotide

• Length: 258 bp

>AT206869 NZ_CP102739:c1483103-1482729 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: D4C5Q8